ID A0A3P8TET3_AMPPE Unreviewed; 666 AA.
AC A0A3P8TET3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Guanylate cyclase soluble subunit alpha-1 {ECO:0000256|ARBA:ARBA00040514};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Soluble guanylate cyclase large subunit {ECO:0000256|ARBA:ARBA00042184};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023144.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000023144.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000023144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A3P8TET3; -.
DR STRING; 161767.ENSAPEP00000023144; -.
DR Ensembl; ENSAPET00000023756.1; ENSAPEP00000023144.1; ENSAPEG00000016318.1.
DR GeneTree; ENSGT00940000158285; -.
DR Proteomes; UP000265080; Chromosome 3.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0090594; P:inflammatory response to wounding; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF4; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 456..583
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 401..428
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 666 AA; 73874 MW; A70325BFF6F60B10 CRC64;
MFCAKLKELK ISGECPFSGS AKNNELGDFE ERATDAADLL PISKDVHGKI GEDLPRQKTS
RAKVNLHTLG ESIQKLACPE FQRLHTALQR MMTLSDHSCA SNPVFFFRMR PTAIPMEALQ
VALGEELFNM SLHDFLNSFN VLLKQSSMQP NPDRGDCVNE PSVLCLDKDP GLLTVYFFNP
SPTTELFFPG VIKAAARLLY HTTVDVLKDP HTAKDSILQS SPQPNLLYTV VVKDAKNLSP
SPLRATSAGT LPTSLFSTVF PFHLILDQDL VLVQIGHGLR KRLTRKDGLR RSATFQEHFS
IVSPQIKCTF QGILTMLNAQ FIIRIKHGVS TTDNTGKLMD LKGQMIYVSE SNAILFLGSP
CVDKLEELTG RGLYLSDIPI HNALRDVVLV GEQAKAQDGL KKRLGKAKAA LEHAHQALEE
EKKKTVDLLF SIFPGTVAQQ LWQGETVQAK KFDRVTMLFS DIVGFTAVCS ICTPMQVITM
LNELYTRFDH HCGELDVYKV ETIGDAYCVA GGLHKESDTH AVQIALMALK MMELSDEVMT
PTGDPIQMRI GLHSGSVLAG VVGVRMPRYC LFGNNVTLAN KFESCSQPGK INISPTTHRL
LKGRPEFVFV PRSRQELPAN FPEDIPGVCY FLEYSTHVAI RSTFDAVTIN LLCSLLYLGK
ECEIDR
//
