ID A0A3P8TF70_AMPPE Unreviewed; 280 AA.
AC A0A3P8TF70;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=CD74 molecule, major histocompatibility complex, class II invariant chain a {ECO:0000313|Ensembl:ENSAPEP00000023324.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023324.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000023324.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000023324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A3P8TF70; -.
DR STRING; 161767.ENSAPEP00000023324; -.
DR Ensembl; ENSAPET00000023943.1; ENSAPEP00000023324.1; ENSAPEG00000016575.1.
DR GeneTree; ENSGT00390000008961; -.
DR OMA; HHNCSEP; -.
DR Proteomes; UP000265080; Chromosome 13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070206; P:protein trimerization; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 1.10.870.10; MHC class II-associated invariant chain, trimerisation domain; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR043530; CD74_antigen.
DR InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
DR InterPro; IPR036613; MHCII_invariant_trimer_sf.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR Pfam; PF09307; MHC2-interact; 1.
DR Pfam; PF08831; MHCassoc_trimer; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PIRSF; PIRSF001992; CD74_antigen; 1.
DR PRINTS; PR01990; CD74ANTIGEN.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF48305; Class II MHC-associated invariant chain ectoplasmic trimerization domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001992-1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..255
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT COILED 60..87
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 198..216
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
FT DISULFID 227..234
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1,
FT ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 236..255
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
SQ SEQUENCE 280 AA; 31182 MW; 96762EA806BCFF28 CRC64;
MAETPDDGRL DTGSLAASEA ALMPRTATRG GSNKRAFKIA GITTLACLLV ASQVFTAYMV
FNQKQQIHTL QRNSDKLNKQ LTRASQSPGA RGPMRMAMPI NTLPLLMDFT SEDTPSKKVE
EPAFVSVEKQ VMDLMQDSQL PHFNETFLAN LQSLQQQMND SEWKSFQSWV RFWLIFQMAQ
EEPAPPTSQP ASLVKTKCQI EAAPGGGKIG TFKPQCDEQG RYKPMQCWHA TGFCWCVDAY
GNPIQGTTMR GRPQCGGGYA PRRMMVAPRM MQKTFVPDDN
//
