ID   A0A3P8TFD3_AMPPE        Unreviewed;       524 AA.
AC   A0A3P8TFD3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=TTYH3 {ECO:0000313|Ensembl:ENSAPEP00000023346.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023346.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000023346.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000023346.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   AlphaFoldDB; A0A3P8TFD3; -.
DR   Ensembl; ENSAPET00000023963.1; ENSAPEP00000023346.1; ENSAPEG00000016569.1.
DR   GeneTree; ENSGT00950000183060; -.
DR   OMA; ECATTIK; -.
DR   Proteomes; UP000265080; Chromosome 14.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF4; PROTEIN TWEETY HOMOLOG 3; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        86..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          488..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..510
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  58677 MW;  E62F6A2ED42E4BF1 CRC64;
     MAAVVSYTPP WWVNLLHRLP HFNLKFEQTS SDFRPEDWTY QQSILLLGGV ALACLALDLL
     FLLIYSICLC CRRNKNEDQP NADCCCTAWC VIIATLVCSA GIAVGFYGNG ETCDGVNRLT
     YSLRHANRTI TGVQKLVYES TTSLNQTVDD DLQQLEVQYA QHADYLSIIQ KLQGQLEELV
     KQMVEIPFWD NNSISLEELA VKIELYDWYR WLGYLSLLLF DVLICLLVLF GLIRNSKGTL
     IGVCLFGVVA LVISWVSLGL ELAVSATSSD FCVAPDTYVT KVSDQYKVIN QEILQYYLSC
     SVEQTNPFQQ KLSGSHKALV EMQDDVSELL RSATREYKQT KGNLEEIQGI LNTTEISLHQ
     LTALVDCRSL HMDYVQAMTG LCYDGLEGLI YLVLFSFVTA LMFSSIVCSV PHTWRGKRSE
     EDSEDESLSH GGRQNHDNLY RVHMPSLYSC GSSYGSETSI PAAAHTVSNA PVTEYMAQNA
     NFQNSRCENT PLIGRESPPP SYTSSMRAKY LANSRPDPNN PAAH
//