ID A0A3P8TGY8_AMPPE Unreviewed; 539 AA.
AC A0A3P8TGY8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023951.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000023951.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000023951.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR AlphaFoldDB; A0A3P8TGY8; -.
DR STRING; 161767.ENSAPEP00000023951; -.
DR Ensembl; ENSAPET00000024582.1; ENSAPEP00000023951.1; ENSAPEG00000017027.1.
DR GeneTree; ENSGT00940000155336; -.
DR OMA; CSQLEEY; -.
DR Proteomes; UP000265080; Chromosome 9.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..539
FT /note="Tyrosinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018299528"
FT TRANSMEM 477..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..222
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 386..397
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT REGION 513..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 60942 MW; B9A2B2CC220BE8A5 CRC64;
MRSLCVSVVL LQLVGTSLCQ FPRLCANSEG LRTKECCPVW EGDGSACGAL SGRGFCTEVQ
VSDEPHGPQY PHSGIDDRER WPLAFFNRTC RCAGNYGGVN CGECRFGYWG SNCAEYRESV
RRNILTLSSA EQQKFISYLN LAKNTISRDY VISTGTRAEM GENGENPLFS DINTYDLFVW
MHYYVSRDAF LGGPGNVWRD IDFAHESAAF LPWHRVFLLH WENEIRKLTG DFNFTIPYWD
WRDAQSCEVC TDSLMGGRSS LSPNLISPAS VFSSWKVICT QPEEYNSREA LCNATGEGPL
LRNPGNHDPN RVTRLPTTAD VDFTVGLPEY ETGPMDRFAN MSFRNVLEGF ASPETGMAVP
GQSTMHNALH LFMNGTMSSV QGSANDPIFV LHHAFIDSIF ERWLRTHQPL RNSYPRTNAP
IGHNDGYYMV PFFPLYRNGD YFLTDKALGY EYAYLLDPGQ RFVQEFLTPY LQQAEQIWQW
LLGAGILGAA IATLFAVLVV VARRKWKRNQ RRKRASSYAE RQPLLHSSSE EGSSYQTTL
//
