ID A0A3P8TJ08_AMPPE Unreviewed; 623 AA.
AC A0A3P8TJ08;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Regulator of G protein signaling 14a {ECO:0000313|Ensembl:ENSAPEP00000023603.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000023603.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000023603.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000023603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8TJ08; -.
DR STRING; 161767.ENSAPEP00000023603; -.
DR Ensembl; ENSAPET00000024231.1; ENSAPEP00000023603.1; ENSAPEG00000016802.1.
DR GeneTree; ENSGT00940000166254; -.
DR OMA; MAKNCNA; -.
DR Proteomes; UP000265080; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17139; RBD2_RGS14; 1.
DR CDD; cd08706; RGS_R12-like; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR046993; RBD2_RGS14.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF2; REGULATOR OF G-PROTEIN SIGNALING 14; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 58..175
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 295..366
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 368..438
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 201..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 67784 MW; 1BCD23BC029B52BA CRC64;
MAKNCNALGI PVGHMSQAVS DGELNMSARG CGGSSSSLPG TPGGESGPAN SVLSWAVSFE
KLLEDPCGVR YFTAFLRSEV SAENILFWQA CEKFKRIPAN SLDELKASAC SIYNTYLSDN
APYSVNIDDT AKTEEKVLEQ PTPDMFNKAQ AQIFKLMKMD SYRRFVRSPL YQNCTLASVE
GKLLPQISTE PVCMGSWEDV GTRSPLSDKK NKKLNSNSLP GGKSASEKQR QKRGSWGDAS
NIHGSGPQKE SHMSVKSTSS VELGSIYRQI ENGGASPRTP EQAGGFGSRI GVEGGYCCVF
LPDGSASLAP TPNGQPIKDM LASLCEKRGF PLKDVIIYLQ GKDKQPLSLD QDCSVLRDQQ
VSLELRVTFA LEIAFTGKTV GIMVKSSKTL QDALSAVMQK HHLKPQEAVI TMVGSDEPVN
MNSIVFRLAN KTIRLDRTKG KDQANISRGS GSSVASQAGA GRAGLETRSS QTDRAKNQLR
PGRNRDMDGL LDMLSRAQCS RVDDQRGLLT KEQLEVPSFL QLPSDQEQET DEPSTSSSST
ADPKVESEEK ISSTSSSASH CQTGHINIQR YEWHTWRCVC ASPSMREWCV GGAMNGQRGV
FSHRHHSSSE MRSAIYSTAR LLH
//
