ID   A0A3P8TJA9_AMPPE        Unreviewed;      1093 AA.
AC   A0A3P8TJA9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Karyopherin (importin) beta 3 {ECO:0000313|Ensembl:ENSAPEP00000025930.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000025930.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000025930.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000025930.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3P8TJA9; -.
DR   STRING; 161767.ENSAPEP00000025930; -.
DR   Ensembl; ENSAPET00000026613.1; ENSAPEP00000025930.1; ENSAPEG00000018395.1.
DR   GeneTree; ENSGT00940000155502; -.
DR   OMA; PKRFVQE; -.
DR   Proteomes; UP000265080; Chromosome 24.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR041653; Importin_rep_4.
DR   InterPro; IPR040928; Importin_rep_5.
DR   InterPro; IPR041389; Importin_rep_6.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF5; IMPORTIN-5 ISOFORM X1; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF18808; Importin_rep_4; 1.
DR   Pfam; PF18816; Importin_rep_5; 1.
DR   Pfam; PF18829; Importin_rep_6; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          344..596
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
SQ   SEQUENCE   1093 AA;  122866 MW;  BB079654B56C8978 CRC64;
     MAEQQQFYLL LGNLMSPDNN VRKQAEETYD TIPGQNKITF LLQAIRDASA AEEVKQMAAV
     LLRRLLSSSF EEIYPGLTLE MQTAVKTELL TSIQQETSPN IRKKVCDIAA ELSRNLIDDD
     GNNQWPEVLK FLFDSVNSDN VGLREAALHI FWNFPGIFGN QQQHYMEVIK RMLVQCMQDQ
     ENPQIRTLAA RAAASFVLSN ESNTALLKHF ADLLPGILQA VNESCYQGDD SVLKSLVEIA
     DTAPKYLRPN LEATLQLCLK LCADTNLTNM QRQLALEVIV TLSETAAAML RKHTAIVAQS
     VPQMLAMMVD LEDDDEWAMA DELEDDDFDS NAVAGESALD RIACGLGGKI ILPMIKQHIM
     QMLQNPDWKY RHAGLMALSA IGEGCHQQME AILQEIVSFV LLFCSDPHPR VRYAACNAIG
     QMATDFAPTF QKKFHDKVIS ALLQTMEDQS NPRVQAHAAA ALINFTEDCP KSLLIPYLDS
     LVQHLHVIMV AKLQELIQKG TKLVLEQVVT SIASVADTAE EKFVPYYDLF MPSLKHIVEN
     AVQKELRLLR GKTIECISLI GLAVGKEKFM PDASAVMQLL LKTQTDFNDL EDDDPQISYM
     ISAWARMCKI LGKEFQQYLP VVMGPLMKTA SIKPEVALLD TQDMENISED DGWEFVNLGD
     QQSFGIKTAG LEEKATACQM LVCYAKELKE GFVEYTEQVV KLMVPLLKFY FHDGVRVAAA
     ESMPLLLECA RVRGPEYLTQ MWHFMCDALI KAIGTEPDSD VLSEIMHSFA KCIELMGDGC
     LNNEHFEELG GILKGKLEEH FKNQELRQAK RQDEDYDEQV EETLQDEDEN DVYILTKVSD
     ILHSVFSSYK EKVLPWFEQL LQLIVQLICP NRPWADRQWG LCIFDDVVEH CSPSSFKYAE
     YFLRPMVQSL CDSSPEVRQA AAYGVGVMAQ YGGENYRPFC TEALPLLIRV IQAADSRSKE
     NVNATENCIS AVGKVMRFRP ECVNVNEILP HWLSWLPLNE DKEEAVHTFD FLCDLIESNN
     PIVLGPDNSN LPKIFLIIAE GVANESVKSE DACSKRLANV IRQVQVSAGL WTQCVSTLNE
     TQQKAIQDLL NTA
//