ID A0A3P8TKI3_AMPPE Unreviewed; 627 AA.
AC A0A3P8TKI3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Fibrinogen alpha chain {ECO:0000313|Ensembl:ENSAPEP00000025141.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000025141.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000025141.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000025141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A3P8TKI3; -.
DR STRING; 161767.ENSAPEP00000025141; -.
DR Ensembl; ENSAPET00000025800.1; ENSAPEP00000025141.1; ENSAPEG00000017871.1.
DR GeneTree; ENSGT00940000157467; -.
DR OMA; RNNMPYE; -.
DR Proteomes; UP000265080; Chromosome 23.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..627
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018081245"
FT DOMAIN 406..626
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 317..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 69013 MW; 8CDA7DCAE3BB92AA CRC64;
FTFKVTEVCF FIAFVIQTTS SKPVTVWFQA QIDPRGARPV EHGTRSEKCA TEKEWPFCTD
DEWGPKCPSG CRIQGLMDKF DHGTVKKIEQ IRSLLEKNKA SHRSTDVTSR QTYDYLKEKL
TLEFGNNNNY YDLAQNLRQR ITDMKIKIDR QIRILAALKD RVKDQVTEMQ RLEVDIDIKL
RSCKGSCASY SEHQVDQDSY VTLDKQINQL DSQFPQNIES VGTLYVMKSK PLQDVIVDSV
YKSKDIGVGT AAQKKDDLFQ EVRVQYAPRM LSSSSVFYVS PSTSHVSTQS VSCTKSIRKT
VVHTKDGPVE KTEEVIEGGP ECQALSDSTK GGMSSLFPSL THTSSSSSSS SHSVHTGGAK
GSLLGDTKTG FVNPFGSDLG GFTMGAVDDD VPDFHARSVN SMRVERQADY VGKDCVDAHR
NHLNGETNGL FKIKPGGGDS AVTVEVYCQQ EGFMGGWLLV QQREGGALDF NRTWAEYRDG
FGSVDAKGKG ELWLGNQNLH LLTAGGETML KVELEDREGG VASAEYTVRI GPEDQGFPLH
VSGYTGDAGD ALAPAHNGMK FSAFDRDASE GSCAERFGGG WWYNSCQTAN LNGIYSKGPN
DPSGVVWATY KPAGLKSVRM FIRSAAF
//
