ID   A0A3P8TLM2_AMPPE        Unreviewed;       475 AA.
AC   A0A3P8TLM2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Solute carrier family 19 member 3a {ECO:0000313|Ensembl:ENSAPEP00000026915.1};
GN   Name=SLC19A3 {ECO:0000313|Ensembl:ENSAPEP00000026915.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026915.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000026915.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000026915.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028739}; Multi-
CC       pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC       ECO:0000256|PIRNR:PIRNR028739}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8TLM2; -.
DR   Ensembl; ENSAPET00000027634.1; ENSAPEP00000026915.1; ENSAPEG00000019109.1.
DR   GeneTree; ENSGT00950000183022; -.
DR   OMA; VKPIEPF; -.
DR   Proteomes; UP000265080; Chromosome 9.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF35; THIAMINE TRANSPORTER 2; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   PIRSF; PIRSF028739; Folate_carrier; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          208..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  53887 MW;  0D037D486F8D8F6A CRC64;
     MEAVKKWRSG WRYPTTLLCI YGFFSTVKPL EPFLIPFMTG PDKNLTTEEV NNQIFPVWTY
     SYLSILVPVF LLTDWLRYKP VVVFQSVVLF ITTSLLLWTE SVAAMQITQF FYAMVTASDV
     AYFSYIYSVI DLKRYRKATS YSRSVQLLGY TVGSVLGQLL VSFNLMSYSN ILVFTLVLTA
     IAVLTSLLLP MPQHSMFFHR RSKMSLEEVG NEKEDKGATE DDTKKGWEGN RPMAEELEET
     VGAQSCTQVL LQLWRDFRQC YSSRQLLYWS VWWAMATCGY NQTVNYVQVL WEHVQPSQNF
     TIYNGGVEAV SNLLSAATAY GIGFTEVGWE QWGELALGGF SGLGAAALFL MTFIGNIWVC
     YCGYVIFKSL YMLLITIAMF QIATGLSMER YALVFGVNTF GALALQTTLT SIVVDSRGLA
     LSIIPQFTIY ASYFSVIAVV FTLRGLYRIW STKRNKKETP SSDQNESPSS REHSF
//