ID   A0A3P8TM32_AMPPE        Unreviewed;       835 AA.
AC   A0A3P8TM32;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000025686.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000025686.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000025686.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3P8TM32; -.
DR   Ensembl; ENSAPET00000026362.1; ENSAPEP00000025686.1; ENSAPEG00000018209.1.
DR   GeneTree; ENSGT00950000182881; -.
DR   Proteomes; UP000265080; Chromosome 14.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        401..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        545..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        572..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        637..661
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        767..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   835 AA;  95612 MW;  AE0DB27B3DA64B32 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPIV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EMEDPSLLEE SSTLLDPNEP NRVAPLRLGF VAGVIGRERI
     PTFERMLWRV CRGNVFLRQA DIEDPLEDPA TGDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RATLYPCPET PQERKEMLAG VNARIEDLQM VLNQTEDHRQ RVLQAAAKTV RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDL DSIQFALRRG TEKSGSTVPS ILNRMQTKQT
     PPTYNKTNKF TSGFQNIVDA YGIGNYREIN PAPYTIITFP FLFAVMFGDL GHGTLMTCAA
     LYLVLRESRL MAQKNDSEIF NMVFAGRYII LLMGIFSMYT GIIYNDCFSK SLNAFGSGWS
     VKPMFMPQRG GNWTFDTLNG NSVLQLDPVV DGVFNGPYPI GIDPIWNIAV NKLSFLNSFK
     MKMSVILGVI HMLFGVSLSL FNHLYFQKPL NIYLGFIPEI IFMASLFGYL VILIFFKWVS
     YDARSSRDAP SLLIAFINMF LFNYDDPSVK PLYRGQMGLQ IFLVIIALAC VPCMLIVKTL
     VLRRQYLWRK HLGTQNFGGI RVGNGPTEDE AEIIQHDQLS QHSEEEPEFN FGDMAVHQAI
     HTIEYCLGCI SNTASYLRLW ALSLAHAQLS EVLWTMVMHL GLSTRSLAGF IFLSIIFCSF
     AVLTVAILLI MEGLSAFLHA LRLHWVEFQN KFYSGQGFKF LPFTFESILD GRFED
//