ID   A0A3P8TPP1_AMPPE        Unreviewed;       420 AA.
AC   A0A3P8TPP1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Acyl-CoA thioesterase 21 {ECO:0008006|Google:ProtNLM};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026556.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000026556.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000026556.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC       {ECO:0000256|ARBA:ARBA00006538}.
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DR   AlphaFoldDB; A0A3P8TPP1; -.
DR   STRING; 161767.ENSAPEP00000026556; -.
DR   Ensembl; ENSAPET00000027265.1; ENSAPEP00000026556.1; ENSAPEG00000018875.1.
DR   GeneTree; ENSGT01010000222336; -.
DR   OMA; KHVIWGG; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006637; P:acyl-CoA metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR   InterPro; IPR014940; BAAT_C.
DR   InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR   InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR   PANTHER; PTHR10824:SF17; ACYL-COENZYME A THIOESTERASE 6; 1.
DR   PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR   Pfam; PF08840; BAAT_C; 1.
DR   Pfam; PF04775; Bile_Hydr_Trans; 1.
DR   PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT   DOMAIN          18..139
FT                   /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT                   acid N-acetyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF04775"
FT   DOMAIN          201..410
FT                   /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08840"
FT   ACT_SITE        230
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT   ACT_SITE        325
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT   ACT_SITE        359
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ   SEQUENCE   420 AA;  46753 MW;  5E62D57C1C655876 CRC64;
     MSSQVRLRLL PSAKCLFDEP VQVKVAGLKS KQLVTMRARS TDEKGVMFSS SATYRADGSG
     EIHLDRDPSL SGTYVGVEPM GLLWSMKPDT LHKRFIKLSS LTPQVVKFSV HEEEGKMLAE
     AINERFLIGD EVSRRPVKEG NIRGVLFTPP GRGPFPAVLD LYTFGGGLSE KRASLLATRG
     FVVLTVALYG HDDQAKNIRE VHMDYFEEAI EFLKRQDKVG SEGVGIISLS KSGDLALSIA
     SYLPGVKATV WINGCSANTA LPLYYKKRLI HSALMFDFEK VIPTESGAVI GRYVLDNPLA
     EENKDALIPI QRAKGHFLFV ASEDDLNWDS KTYMDEMVER LKRHGKDNFD SVSYPEAGHY
     LEPPYGPYCP SSFHGVVRRP VVWGGEARSH AAAEVHMWKK VQEFFRTHLS CDAAQTNPKL
//