ID A0A3P8TQB3_AMPPE Unreviewed; 882 AA.
AC A0A3P8TQB3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000025227.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000025227.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000025227.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3P8TQB3; -.
DR STRING; 161767.ENSAPEP00000025227; -.
DR Ensembl; ENSAPET00000025889.1; ENSAPEP00000025227.1; ENSAPEG00000017952.1.
DR GeneTree; ENSGT00940000156323; -.
DR OMA; SFVKSEW; -.
DR Proteomes; UP000265080; Chromosome 23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..882
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018220796"
FT TRANSMEM 661..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 720..875
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 23..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 882 AA; 98288 MW; 22D8C9EA7AE7FC00 CRC64;
MRRPTSCQLA LLLLLFLNLC RGQGSDSGEG RSDSGEGRSD SGDGRSDSGD GRSDSGDGRS
DSGDGRSDSG DGRSDSGDGR SDSGDGGSDS GDGRSSCHRC DSHLSCNCSH GGFTHIPVVT
DRALTIDLSC NAIATVMDDD LMGHTRLRAL DLHGNGLAAI QPSAFDSLWS LEELDLSDNQ
LAALNYRWFR KLEALQQLNL LSNPYSCLGS PPLFQGLVRL RRLAFGGPAL EELRRGDLSG
VTQLEELTVH ANNLTRYESG TLADIWPLGH VTLSLHGPFL TNMPVASAVL GDVSYPETPI
TLEDLHLIGN WSVQPLRESA RKRIRHLSFR NLSVSDEAVV SLLVVVDGVP ITYLSVDGIT
LTGEGRWEKA SYTDQRSIDE FFAQDVVVLD VFKFFSLLDL KFLLQYPRRV SVINSKVFVM
PCITSKLLVN LQYLDLSDNL LTDLTLVETL CGDHETLKEL RVLNISGNPL KSLSTVSRLV
TKLSKLTHLD VSRTGYISMP PSCPWPSTLR HLNISGAKLT TTTPCLPATL EVLDLSNNNL
RGFTQHLPVL RELHLSGNKF LSLPPGQLFP NLQTLTIHSN TLNMFGRLDL QSFRRLESLQ
AGQNQFVCSC DFVNFLQSAL KGHEGIHLTD GEDNYVCDSP LYLQGEPVGR VHLSIVTCHR
VLFVSVSCGL VLVVGVLLGV LLWRLHAFWY LKMTWAWLKA KHSSRRRQRH RVVEGSEALL
SFDAFVSYSE RDAGWVENFL VPELEEPSES DSGDPRTSRS LTLCLHKRDF LPGHWIVDNI
MSAMERSRRT VFILSENFVQ SDWCRYELDF SHFWLFDGHA GGEAAILVLL EPLSKDDVPK
RFYKLRKLMS STTYLEWPRE EERRPEFWRS LRKALRGGDE DD
//
