ID A0A3P8TRD3_AMPPE Unreviewed; 406 AA.
AC A0A3P8TRD3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Par-6 family cell polarity regulator alpha {ECO:0000313|Ensembl:ENSAPEP00000025607.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000025607.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000025607.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000025607.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the PAR6 family.
CC {ECO:0000256|ARBA:ARBA00008625}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8TRD3; -.
DR STRING; 161767.ENSAPEP00000025607; -.
DR Ensembl; ENSAPET00000026281.1; ENSAPEP00000025607.1; ENSAPEG00000018193.1.
DR GeneTree; ENSGT00950000183211; -.
DR Proteomes; UP000265080; Chromosome 4.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd06403; PB1_Par6; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034868; PB1_Par6.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14102; PAR-6-RELATED; 1.
DR PANTHER; PTHR14102:SF9; PARTITIONING DEFECTIVE 6 HOMOLOG ALPHA; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 14..96
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 162..255
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 253..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 43902 MW; 5CAD4A3021EAD9AA CRC64;
MQRNQRPECS TQIDVCVRCH LQFEAEYRRF ALKRNGPGGF QEFYRLLQTI HRIPGVDVLL
GYADVHGDLL PINNDDNFHK AVSSANPLLR IIITKKEDDP VVFATNSLQR RKKGLGLTGL
RTTGSGSTHS KNKSGLMIGL PQNFRQISSI IDVDILPETH RRVRLHKHGT HKPLGFYIRD
GVSVRVTPQG VEKVPGVFIS RLVRGGLAEN TGLLGVNDEI LEVNGIDVAG KSLDQVTDMM
VANSHNLIVT VKPANQRNNV VHRGSKSSVG NSGSVGSAGS TGSALLHDSP SPASQSNPIT
ASTAEGDSDD EDDDADLILE NDCLTPYDSH RVANSNSTNL NRDSPSNRPH NFAVGRPFPQ
SVSLPNSIGA SLSDSSVMMS NHNGNPSHTA SSSQESMRED GNTITL
//
