ID A0A3P8TSF4_AMPPE Unreviewed; 399 AA.
AC A0A3P8TSF4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Delta like non-canonical Notch ligand 1 {ECO:0000313|Ensembl:ENSAPEP00000026178.1};
GN Name=DLK1 {ECO:0000313|Ensembl:ENSAPEP00000026178.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026178.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000026178.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000026178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8TSF4; -.
DR STRING; 161767.ENSAPEP00000026178; -.
DR Ensembl; ENSAPET00000026865.1; ENSAPEP00000026178.1; ENSAPEG00000018555.1.
DR GeneTree; ENSGT00940000154225; -.
DR OMA; IFFNRCE; -.
DR Proteomes; UP000265080; Chromosome 18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF29; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..399
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018223427"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..55
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 88..125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 127..170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 172..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 45..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 115..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 239..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 399 AA; 43367 MW; 8AC2D4DDC4DEE2E0 CRC64;
CFMLLFLIFD TNTLLSFPFC LKGWECSAGC NTENGFCEKP GKCRCKPGWQ GDNCDQCVPF
PGCLHGTCEK AWQCICKEGW VGSLCDQDTR LCSSRPCASN ATCIETGEGG YLCICPHGYA
GDNCHLKRGL CLTNGYHSPC QNGGTCTDAD GSAAYSSCLC PPGFSGDFCE ISVDSCQPNP
CLNGGNCTNH GLAFTCVCPH GFTGFTCNDT TSLSPCAGRP CANEGTCVGQ PDGTFRCICQ
KWFTGPTCSL QHRPKTRSKP VGARPADHRV FALTPQHYSL PAHAFHKLLR PPERDLLKIT
LKETVHSSGV LVTHGQLVCF GMLALLTCLV ILGTTGIVFF GRCETWLANA KYSQLVRQQR
EHLLREAGST SQEEPEHSVN IILPEKIRLT SFGRHYTSI
//
