ID A0A3P8TSV6_AMPPE Unreviewed; 1086 AA.
AC A0A3P8TSV6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSAPEP00000026122.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026122.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000026122.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000026122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3P8TSV6; -.
DR STRING; 161767.ENSAPEP00000026122; -.
DR Ensembl; ENSAPET00000026807.1; ENSAPEP00000026122.1; ENSAPEG00000018477.1.
DR GeneTree; ENSGT00940000156972; -.
DR Proteomes; UP000265080; Chromosome 12.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 476..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 510..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 553..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 589..607
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 691..709
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 729..747
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 777..796
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 817..841
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 877..899
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 949..966
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 972..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 143..399
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 447..955
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 54..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..72
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 122546 MW; ABF4A63BB1758A42 CRC64;
MILSVCFCVL QRNDDEAVVD RGGTRSQQRT NFEQEDLEGH RTLYIGVHVP LGSTRHRSHR
RHRHHGTKYR KRSRERTMPL VEGRESPAYD TPSQRVQFLL GTEDDDEEHI PHDLFTEMDE
ICLRDGMDSE WRESARWLKF EEDVEDGGER WSKPYVATLS LHSLFELRSC IINSTVLLDM
RANSIEEIAD MVLDHQELYS PLGDELRKKV RETLLKQHHH QNQKKLANRL PIVRSFADMG
RRTSELHLDK NGQLSASQSQ LAAPDGKGDI SKDSSSVDFS KIDLHFMKKI PAGAEACNVL
VGELEFLNKP VVAFVRLSPA VLLNGLAEVP IATRFLFILL GPLGRGPQYH EIGRSIATLM
TDEVFHDVAY KAKDRNDLIA GIDEFLDQVT VLPPGEWDPS IRIEPPKNVP SQEKRKKSNI
LPNGLVEGEE EEEHGGHGGP ELQRTGRWFG GLFLDIKRKA PHYLSDYTDA ISLQCVASFL
FLYCACMSPV ITFGGLLGEA TEGRISAIES LFGASLTGIA YSLFAGQPLT ILGSTGPVLV
FEKILFKFCK EYGLSYLSLR TCIGLWTAFL CIVLVATDAS SLVCYITRFT EEAFASLICI
IFIYEALEKL FHLGVHFPFN KNNNLDKLTM YSCSCVEPSD PTNGTLKFWE INNITATEIY
WEALEVKDCI EKRGEFVGSA CGPHGPYVPD VLFWCVILFF STVFMSAFLK EFKFSNYFPT
KVRSVISDFA VFFTILTMVL VDYALGIPSP KLKVPSVFKP TRDDRGWFIN PLGPNPWWTA
VITVVPALLC TILIFMDQQI TAVIINRKEH KLKKGCGYHL DLFMVGVMLG VCSLMGLPWF
VAATVLSITH VNSLKLESEC SAPGEQPKFL GIREQRFTGL MIFVLMGCSV FMTSVLKFIP
MPVLYGVFLY MGASSLRGIQ FFDRLTLFGM PAKHQPDFIY LRHVPLRKVH LFTIIQLSCL
ILLWVIKTSK AAIVFPMMVL ALVFIRKLMD CIFSKRELSW LDDLMPESKK KKLEDAEEEE
EQSILAEDEG LVQVPLEGFK GIPIINITDE MSKGSFGNTW NANTALDDDK EQESSESLTT
FHCLSL
//
