ID   A0A3P8TT08_AMPPE        Unreviewed;       794 AA.
AC   A0A3P8TT08;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=RAS p21 protein activator 2 {ECO:0000313|Ensembl:ENSAPEP00000026172.1};
GN   Name=RASA2 {ECO:0000313|Ensembl:ENSAPEP00000026172.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026172.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000026172.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000026172.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8TT08; -.
DR   Ensembl; ENSAPET00000026858.1; ENSAPEP00000026172.1; ENSAPEG00000018523.1.
DR   GeneTree; ENSGT00940000158201; -.
DR   Proteomes; UP000265080; Chromosome 9.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd05394; RasGAP_RASA2; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          1..115
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          116..238
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          304..498
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          552..653
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   794 AA;  90632 MW;  1784A52B92F38AC7 CRC64;
     MAEEDDARIR ILQSLRGKIC EAKNLGPVSG PNRQRDLCTF CTISLDQEEV FRTKVFDKSV
     SPFYGEDFYF EIPRPFQCLS FYVYAKSVFQ RDLPVGKVSI RKDDLCKYSG KEHWFSLHPV
     DPNSEVQGKV HLEMRLNEVI TENGSLGQHL VVRSDQKKTK VKKKTSNPQF EETFFFEVTR
     SSSYSKKSHF QVEEEDIEKL EIKVDLWNNE NLAQDVFLGE TRVPVKILRN DHIHKAWYLL
     QPKGNGSKSK SDDLGSLRLK LTYIEDTVLP SACYTPLCNL LLKSPDVKPI SASAAHILGD
     ICRERYEAVL PMVRLLLHHN RFVPFVSAVA ALELDNTQEA NTIFRGNSLA TRCIDDMMKI
     VGKNYLAVTL KPVIDEICDS NKACEIDPNK LKEGDNVEVN KENLQVYVQK VFSSITQSSS
     SCPPLMCDVF RSLRHLACKR FPGDPHVQYS AVSSFVFLRF FAVAVLSPHS FQLRSHHPDP
     EISRTLTLIS KTIQTLGSWG SLSKKLSSFK ETYMYDFFKS FQEDKCIEKV KKFLDEISSN
     VSKESSGLED AVVLKEGEVQ KRAQGRKRLG KRNFKKRWLR VTNRELSYHK HKGKEALCTI
     SVKNIQAVEK LDESAFNRKN MFQVVHSEKP LYVQAGNCVE ASEWLEVLGQ VTRCNEGRLA
     TFHPSNYTSG SWQCCKSQSN SAPGCKPCTT TMLANLQLDI DCDRETERIF SFLSSNDTKL
     QNMEDACASM AVYQGPQREQ EEYSKFTIQE PKETFQTLKQ LRNIMEELQR QHNIRNDTAA
     QYGSLDNPIV GKTS
//