ID   A0A3P8TT61_AMPPE        Unreviewed;       423 AA.
AC   A0A3P8TT61;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Acyl-CoA thioesterase 21 {ECO:0008006|Google:ProtNLM};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026413.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000026413.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000026413.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC       {ECO:0000256|ARBA:ARBA00006538}.
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DR   AlphaFoldDB; A0A3P8TT61; -.
DR   STRING; 161767.ENSAPEP00000026413; -.
DR   Ensembl; ENSAPET00000027116.1; ENSAPEP00000026413.1; ENSAPEG00000018776.1.
DR   GeneTree; ENSGT01010000222336; -.
DR   OMA; CTNERWF; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006637; P:acyl-CoA metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR   InterPro; IPR014940; BAAT_C.
DR   InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR   InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR   PANTHER; PTHR10824:SF17; ACYL-COENZYME A THIOESTERASE 6; 1.
DR   PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR   Pfam; PF08840; BAAT_C; 1.
DR   Pfam; PF04775; Bile_Hydr_Trans; 1.
DR   PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT   DOMAIN          18..141
FT                   /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT                   acid N-acetyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF04775"
FT   DOMAIN          204..413
FT                   /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08840"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT   ACT_SITE        328
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT   ACT_SITE        362
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ   SEQUENCE   423 AA;  46595 MW;  6FC3DF2CB17F8133 CRC64;
     MSSQVRLRLL PSAKCLFDEP VQVKVAGLKS KQLVTMRARS TDDKGVMFSS SATYRADGSG
     EIHLDRDPSL SGTYVGVEPM GLLWSMKPDT LHKRFIKLSS LNPHVVKFSV HEEEEEESKM
     LAEVINERIL IGDGVSRLPV NKGNIRGVLF TPPGRGPFPA VLDLYTFGGG LSEKRASLLA
     TRGFVVLTVA LYGHDDQAKD VKAVHMDYFE EAIEFLKTQD KVGSEGVGLI SLSKSGDIAL
     SIASYLPGVA ATVWINGCSA NTVLPLHYKK REIHSVLTYD AKKAFLTETG AVNIKYVLNS
     PLLDENKTAL IPIERAKGHF LFVASEDDCN WDSNTFMNEM VERLKRHGKE NFESVSYPEA
     GHYLEPPYGP YCPSSVHGVV GMPVVWGGEA RSHAAAEVHM WGKIQEFFRT HLSCDAAQTN
     PKL
//