ID A0A3P8TTJ9_AMPPE Unreviewed; 507 AA.
AC A0A3P8TTJ9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=WASP like actin nucleation promoting factor b {ECO:0000313|Ensembl:ENSAPEP00000026518.1};
GN Name=WASL {ECO:0000313|Ensembl:ENSAPEP00000026518.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000026518.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000026518.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000026518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8TTJ9; -.
DR Ensembl; ENSAPET00000027227.1; ENSAPEP00000026518.1; ENSAPEG00000018803.1.
DR GeneTree; ENSGT00730000110895; -.
DR Proteomes; UP000265080; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR CDD; cd22075; WH2_hN-WASP_r2_like; 1.
DR CDD; cd22074; WH2_N-WASP_r1; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR13037; FORMIN; 1.
DR PANTHER; PTHR13037:SF23; NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR Pfam; PF02205; WH2; 2.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00461; WH1; 1.
DR SMART; SM00246; WH2; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 2.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
DR PROSITE; PS51082; WH2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 30..137
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 196..209
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 406..423
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 435..452
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 266..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..392
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..507
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 54890 MW; 2E5372D5A048D2DD CRC64;
MSGHPPQRRQ ANVGSILLTP QENEALFNHL GRKCITLSSA VVQVFTADRN SSWNKRCCGV
ACLVKDNPQR SYYIRVFDIR DGKMMFEQEL YNNFSIYLPK PYFITFAGDT CQVGLNFANE
EEAKRFRSNV TELIGRRQRK TGPTLPMATV DIKNPEINSV QRYHNNSQVN NIVHSSFQKR
EKKGKGKKKR LTKADIGTPS NFQHIGHVGW DPNTGFDLNN LDPELKHLFD MCGISEAQLK
DKETSKVIYD FIEKKGGVEA VKNELRRQAP PPPPSRGGPP PPPPHHSSAP PPPPPARGRG
APPPPPPSRA PVSAPPPPPP SRPGMGAPPP PPPSRGSLPP PPPPAHASIP VAPPPPPPPP
SSSTPSSTGV PPPPPPPPPP PGPPPPAPPP SMEANGGDSG PPSSGNKSAL LSQIREGTQL
KKVEQKERPV SSSTGRDALL DQIRQGIQLK SRDDNSDSTP STPAPSAGIV GALMEVMQKR
SKAIHSSDED DDDEDDEDFE DDDEWDD
//