ID A0A3P8TTN0_AMPPE Unreviewed; 422 AA.
AC A0A3P8TTN0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=UDP-sugar transporter protein SLC35A5 {ECO:0000256|ARBA:ARBA00040377};
DE AltName: Full=Solute carrier family 35 member A5 {ECO:0000256|ARBA:ARBA00041937};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000029475.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000029475.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000029475.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in
CC UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-
CC glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport
CC from the cytosol to the lumen of the Golgi.
CC {ECO:0000256|ARBA:ARBA00037779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:67138;
CC Evidence={ECO:0000256|ARBA:ARBA00036186};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:57865;
CC Evidence={ECO:0000256|ARBA:ARBA00036522};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-
CC glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:58052; Evidence={ECO:0000256|ARBA:ARBA00036726};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR AlphaFoldDB; A0A3P8TTN0; -.
DR STRING; 161767.ENSAPEP00000029475; -.
DR Ensembl; ENSAPET00000030268.1; ENSAPEP00000029475.1; ENSAPEG00000020922.1.
DR GeneTree; ENSGT00950000182827; -.
DR OMA; SCLKWAV; -.
DR Proteomes; UP000265080; Chromosome 12.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF90; UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 398..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46738 MW; CC45D27366156564 CRC64;
VSFSLGSPAS SHTMACCHSC PRLCSRSVAY TLALGLGSVT LGTSRTLLLK FSENAENKYD
FLPASVNLLA EALKLLFCLV MSVRVIIREG RSCRELGFAS SSPFLSSLKW AVPAFLYFLD
NLIAFYVMAY LQPVMTVLSS NLVILTTAVL FRIVLKRRLS WVQWAALVIL FLSIVSLTTG
SASSQNSNAV PGHHAKPVRP VQLLLAVHSA SGSSRRTAWR SRVMERLLCL GAGHILLLLQ
CFIAAMANIY NEKILKDGDQ LTESIFIQNS KLYAFGVVFN GLTVWAQGLH HDLLHGHNVY
SLGLVPVTAA LGLSVAFILK FRDNMFHVLT GQITTVLVTG LSFFLFDFHP TRHFFLQAPM
VLLAIFIYNA SRLKDPEYSL QQEKLRVING EVFERSRGDG EELELLTKPN TDSESEEDSP
QF
//
