ID A0A3P8TVC3_AMPPE Unreviewed; 1891 AA.
AC A0A3P8TVC3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000027042.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000027042.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000027042.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 161767.ENSAPEP00000027042; -.
DR Ensembl; ENSAPET00000027764.1; ENSAPEP00000027042.1; ENSAPEG00000019129.1.
DR GeneTree; ENSGT00940000163423; -.
DR OMA; KDFPKNG; -.
DR Proteomes; UP000265080; Chromosome 12.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 120..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 149..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 395..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 645..663
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 675..698
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 755..783
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 845..868
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1106..1124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1145..1164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1170..1191
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1222..1248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1341..1365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1424..1442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1454..1472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1484..1504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1541..1569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1645..1668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 147..428
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 456..568
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 644..874
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 882..1100
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1104..1374
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1423..1678
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 419..453
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1850..1868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1869..1891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1891 AA; 214613 MW; B58166F6D9B7D6B2 CRC64;
MEQLLVPPGP DSFRRFSRES LQAIEKRIAE EKAKKPKGEK RKRNDENELK PSRDLEAGKS
LPLLYRDIPA GMVSTPLEDL DPYYSNQKTF IVLNKGKFIF RFNAAPALYL LSPFNPLRRI
SIWILMWLII PKTALILQEH SLTTACKLFS MVIMCTILTN CAFMTLSQPP EWAKNVEYTF
TAIYTFESLV KILARGFCIG KFTFLRDPWN WLDFCVIVMA YVTEFVPLGN FSAVRTFRVL
RAFKAISVIP GLKTIVGALF QSVKKLADVM ILTVFCLSVF ALVGLQLFMG NLMQKCLRWP
RNDTDETDDF TAYSLNEENY YFLPGKRDPL LCGNASEAGQ CPEGFTCMKI GRNPDYGYTS
FDSFGWAFLA LFRLMTQDYW ENLYQQTLRA AGKPYMIFFV LVIFLGSFYL VNLILAVVAM
AYEEQSQATI KEEKEKEEEF QAMLEQLKQQ QEDAQSFLSF RGPLFSPRRN SKTSLFSFRS
QVQDMGSENE FADDENSIFE DNLSRRGSLF FPQRCDRRSS SMSQCIFMPR LRLPPSGIRH
SSVDCNGVVS LVGGSSLPAS PVGLLLHATG GTYQEFLDPF EGPEARQRAH SIASVITSTM
EELEESRQKC PPCWYNFAHT FLIWECCPLW LKIKKMVRLI VMDPFTDLTI TICIVLNTLF
MAMEHHPMST GFSNMLTVGN GVFTAIFTAE MVLKIIALDP YYYFQQGWNI FDSIIVSLSL
MELGLADVAG MSVLRSFRLL RVFKLAKSWP TLNTLIKIIG NSVGALGNLT LVLAIIVFIF
AVVGMQLFGK KYKDCVCKIS PECVLPRWHM NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG
TTKCIIVYMM VMVIGNLVVL NLFLALLLSS FSADNLAATD DDSEMNNLQI AIGRIHKGIA
FTKSLLRSCC SSVCLRGKKK KKDEDKALDE LHKPLGPNGV ANHLIKDFPK NGNGDVTGVD
KNGDKYIVCS KSDDSIMSFI NNPSLTVTVP IAVGESDFEN LNTEDFSSAS SEVAACHMVR
MLFSVKIIED DGQFSSSEGS TVDGLPAGEG GDSLDFELEE AMDPDACFPA ACVQRFKCCQ
VNVDVGFWKI WWTLRKTCYR IVEHNWFESF IIFMILLSSG ALALEDVYIE KRKTIKTMLE
FADKIFTYIF ILEMLLKWVA YGFAKYFTNA WCWLDFLIVD VSLVSLIANA LEINELGPIK
SLRTLRALRP LRALSRFEGM RVVVNALLGA IPSIVNVLLV CLIFWLIFSI MGVNLFAGKY
YSCVNRTTDK PLLPTIVKNE TECLALSNET VRWKNVKINF DNVGMGYLAL LQVATFKGWM
DIMYAAVDSP NQPEYEKNLK MYVYFVVFII FGAFFTLNLF IGVIIDNFNQ QKKKIRGQDI
FMTEEQKKYY NAMKKLGSKK PQKPIPRPSN KIQGYIFDFT TKQAFDIAIM VLIWLNMVTM
MVETADQSPQ KTEVLQKINV FFIVVFSGEC LLKVISLRQY YFTSGWNIFD FIVVILSVLG
MFLSEMIKKY FVSPTLFRVI RLARIGRVLR LIKSAKGIRT LLFALMMSLP ALFNIGLLLF
LVMFIYAIFG MSAFAYVKRE RGIDDLFNFE TFGNSMICLF QITTSGGWDG LLYPILNRHQ
DDCNSSKEHP GSTVVGDCGN PPVGIAFFVS YIIICFLIVV NMYIAVILEN FGVATEESAD
PLSEDDFEMF YEVWEKFDPR ATQFMEYYKL SEFADALDPP LRIAKPNKIE LISMDLPMVS
GERIHCLDIL FAFTKRVLGE GGEMDILRGQ MEERFMASNP SKMSYEPITT TLRRKQEDTS
AVVIQRAYRQ YVKNSQGIGI RPSDMSNGNI QKDEKVIEKE DLAADKQKSE LTPSAASQPS
CNSVTTNGKN KYEKDKSEKE VESKDVTAED I
//
