ID A0A3P8TWI5_AMPPE Unreviewed; 728 AA.
AC A0A3P8TWI5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dishevelled segment polarity protein 1a {ECO:0000313|Ensembl:ENSAPEP00000029021.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000029021.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000029021.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000029021.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
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DR AlphaFoldDB; A0A3P8TWI5; -.
DR STRING; 161767.ENSAPEP00000029021; -.
DR Ensembl; ENSAPET00000029790.1; ENSAPEP00000029021.1; ENSAPEG00000020594.1.
DR GeneTree; ENSGT00950000182903; -.
DR OMA; SRTNGHP; -.
DR Proteomes; UP000265080; Chromosome 8.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd04438; DEP_dishevelled; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR024580; Dishevelled_C-dom.
DR InterPro; IPR008339; Dishevelled_fam.
DR InterPro; IPR003351; Dishevelled_protein_dom.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR PANTHER; PTHR10878:SF5; SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF02377; Dishevelled; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF12316; Dsh_C; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01760; DISHEVELLED.
DR PRINTS; PR01761; DISHEVELLED1.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 1..85
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT DOMAIN 256..328
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 406..480
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 89..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..537
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 79709 MW; C93A3B39818CF1C8 CRC64;
MAETKIIYHI DEEETPYLVK LSVSPEKVTL ADFKNVLNNR PVNSYKFFFK SMDQDFGVVK
EEISDDNAKL PCFNGRVVSW LVLAESAHSD GGSQCTESHP ELPPPLERTG GIGDSRPPSF
HANAVSSRDG LDTETGTESL LSHRRERERE RARRRARETE LPRINGHSKS ERTARDSAMG
YDSASVMSSE LESSSFVDSE EDEDASRLSS STEQSSSSQL MRRHKRRRRR HKVAKIDRSS
SFSSITDSTM SLNIITVTLN MEKYNFLGIS IVGQSNDRGD GGIYIGSIMK GGAVAADGRI
EPGDMLLQVN DVNFENMSND DAVRILREIV SKTGPISLTV AKCWDPSPRS YFTIPRAEPV
RPIDPAAWIS HTTALTGPYP HYEFDDLPLS ASKTDMATIV KVMQLPDSGL EIRDRMWLKI
TIANAVIGAD VVDWLYSRVE GFKDRRDARK YASSLLKHGY LRHTVNKITF SEQCYYTFGD
LCQNMASLNL NEGSSGGGSE QDTLAPLPPT SNPWPLGGQP FPYPPFPSAP PSFPPGYSDP
CHSFHSGSAG SQHSEGSRSS GSNPSAGKGR RSSPQEKGHR STCSESEPGV RGGRRGDRSA
SQMSHHSHAV SSHSHARSSL SHSHSHRSHT LSQNNHPPFT YSHAPFTQPA PGSCAQSERS
HASSYGPPGL PPPYCLARLA PKTPVSSSTP PGAPPGRELA AVPPELTASR QSFQHAMGNP
CEFFVDIM
//
