ID A0A3P8TYI7_AMPPE Unreviewed; 3972 AA.
AC A0A3P8TYI7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Fraser extracellular matrix complex subunit 1 {ECO:0000313|Ensembl:ENSAPEP00000028157.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000028157.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000028157.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000028157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 161767.ENSAPEP00000028157; -.
DR Ensembl; ENSAPET00000028905.1; ENSAPEP00000028157.1; ENSAPEG00000019848.1.
DR GeneTree; ENSGT00940000163761; -.
DR OMA; NSGMRVQ; -.
DR Proteomes; UP000265080; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0010669; P:epithelial structure maintenance; IEA:Ensembl.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR CDD; cd00064; FU; 12.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 4.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 5.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3867..3888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..63
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 119..179
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 181..241
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 245..311
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 315..373
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1061..1158
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1178..1268
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1289..1400
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1425..1521
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1557..1652
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1673..1774
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1797..1898
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1920..2020
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2041..2140
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2162..2254
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2274..2367
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2402..2499
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 3972 AA; 437600 MW; B86A2D1AE4EF0048 CRC64;
SLNLHLFLAA ANDSSWRPES CQECRCHGDV SICRTTSCPN PNCDFQRGER LRIPANQCCP
ECVSSSQSSC HYQGLTYGDD SQWSPSSCSL CVCSRGSVSC STLFTPEGEC CPKCGRNGAS
CSWQGAPYRD GQQWNPSSCS RCSCSDGQVQ CWVAECRQVA CKPDENLVIP AGQCCPQCVS
NPCLSAGKQY QHGQQWRKDD CTTCVCDRGQ SRCNTDTCRS ITCDKGQTNV RRAGSCCDEC
AAAKGSCLYQ SAVRYHGDMW NATGCEFCSC DRGQVLCQRA ECGTGHMSQV SKKREEKGLV
HLPGKCCPEC SSVKPACIYH GESYQNLARW TDGSCRECEC RDGQVTCYLS SCPTCPPGTL
AVVQEGRCCP DCHQAQCHAD CLSCSGSPDH CESCSDPKSF LHLGRCLSVC PVGFYTEGRV
CAACQPSCSS CSSRWDCDSC GSQLPLLGPD SGRCLASCPG GSYQHDQTRC RRCHPSCSDC
RGPTQQDCIS CSDPVALLKD GVCVPDCGAG FYSQDGICYG CDSSCASCFP DNPKCMSCPP
GTALHHGKCV TQCPAQHYLD GHHRCRACHS SCASCWGPSV SQCSSCPAGL LLHQGQCVEA
CGEGLYAHDT TCHNCHPSCR SCVGPLASDC LRCLKPEETL LRQSGHLHHG VCTAGCPANS
FLDDTQTCRD CHPSCWHCSG PSADNCTSCS SPSSLLEGRC VQTCPQGFFM QDDRCQACHP
SCLSCSGPSQ ADCTSCPPLA SLQGGYCRTS CQDGLFLHAV TGECLRCSPD CQRCTADLQT
GVGSICLWCK APRTWLLGDH CVSDCPPGRY AWHGACIKCH ASCESCSGAG PLSCTSCPSG
GVLLPSGLCA PKCPLGYHDN GHRICQVCDS QCLTCDMPGV CTSCRDPTKV LLFGECQYDS
CAHQYYLNTT TRTCRECDWS CNACKGPQRT DCLQCMDGYV LQDGVCSPGC SLGSYQDGDR
CLACDDHCME CGGPGQCQEC QPPYATLQGQ CVLECGRNHF LDASFKVCKS CSSDCVLCDG
VGQCRACRHQ TYLMEGYCTP DCGHGYYADQ KTRTCHVNVH PPVLHVNGSL LVPLDGLAPI
TSSLLQVKDQ DSPTDRLIFH LVQTPSNGRL VLVGGEEGGE EELTEDETFS WTDLNLGRVR
FRHQKDKTRS GEFKLRVSDP QLFSRPETVQ VQAVSMQPPS ILTLSVLPVE GRGSSATVTK
ATLQLDDPDN PADVLVIVLE PPRHGRLARL HGDRALSRFK LEELSREQIR YVHDGSQAEQ
DVTVLQVNDG HSYRNVLLRV SISQKAADSP HVLSLLRTWV KEGGMVRLDR KYLKTDYKGV
STDDIVYTIL GSDLQPKYGE VVLVSMPADG PSEGWRPSLA NDRGFTPTTS FTQQDVNDGT
VWYRHFGSGS SSDSFQFQVS TEAAPLVQSD AQTFTIGVLP QTPGFPQLAP ECDLQITALE
DRVTELTASA LSFVDAETPN EKLIYNITKP LPPGQGAIEH RDRPYVPAKH FTQADVNNGK
IVYRPPPAPS HLQELYQYSF IGLPESLSVY FTVSDGEYTT PELDFAVLLL SNHHQPPVFQ
VLDPLLEVSR GGQASIGGQQ LAVSDADTAP DELEFELVEA PIHGELIRTD SKTNTRMANG
DIFTFSDVTR NVLLYRHTGL SAQDDAITFS VSDGISMATT VVQVAVLGAG GDGPQRDPAA
TLSLEVGEKS SSVIRRSNLA YTDDTSPDDQ IRIQLVSVPM YGILTRSQSQ QEHQELREYS
FFTMEDINKS RIRYITSLET GSQPVTDIFH FVVHDGDNNR LDNQMCTITI TSTPRQPPTV
TVRSGIKVQE GGRVQLSTNH IIISDVDTPR KDLLVWLVSP PKYGFLENTK RGSVGGSRII
TPDVPFSVDD LTSDHIFYVQ DGSQKPKTKQ DVFSLYISDG HSQTEAFSVE IDVQESKEDR
QPLVSVSSIH VEENSGVVIT NSSLSVLDQD TPENEILFTI IRIPSYGKLR RRQFYSQPLE
NGRVLTQGST FTYQDVLDQL LVYTPETVSG GADEMGFTLT DGIYTHTGRL QFTMDVRRSE
GPRMTVNRGL QLPAGSSSKI TEQNLKGTDI DSDILKLRYF LTKDPPFGKL QLSKSSRVEK
VSVKGPLQSF TQDDVNKGLL QFSHEKGEKG GSLSFKFNLV DPEGNKLIDQ SFFISVLEDR
LPPSVVVNKG LVLDENTMKK LTMLQLSASD QDSEPGDLIY RITKQTSLGH LEHAANPGTR
IGSFTQADLA SRSVQYVHTS EEEKHADQFS FTVSDGNNEV AQTFYITIKP VDDSLPLLQV
PGMRVQEGVR KTITEFELKA TDADTEAESI VFSVVQPPRH GAIERTINGQ HYRQTSSFTM
DDIYQNRISY NHDGSNSLKD RFTFTVADGT NLLFMVEDGG KEIVTAAPQK FKIDILPVDD
GTPRIVTNLG LQWLEYMDSK ATNLITKKEL LTMDPDTDDA QLVYEITTEP KHGFLESKVK
PGNPVSTFTQ ADINLGLIRY VLHQENVQET MDNFKFLVKD SKPNVVSDNV FHVQWSLISF
EHKSYNVSEK AGTVAVTVKR TGNLNQYAIV LCRTEQGSAT STSSTGSKPG QQDYVEYAGQ
VQFDEREDTK VCTIVINDDR VFEDVESFQV ELSMPVYALL GGKTRATVNI NDTEDEPTLQ
FDKKTYHVNE STGFIHAPIE RKGDSSSTVS ALCYTVAKSA QGSSLHGLES GSDYKSRGMT
TDNRVVFGPG VSMSTCDVKL IDDSEYELSE EFELVLSDAS DNARMGDVSV AKVVIDGPND
ASTVSLGNAT FTFSEDAGTI EIPVLRHGSD LSSVTSVWCA TRPSDPPSAS PGVDYIPSSK
KVEFKPGKTE ETCSLTIMDD IQNPSIEGSE SFVVFLSSPQ GAVLQEPYEA NVVITDTFQD
IPSMQFEKSS YIVKEKDNVL HIPIVRTGDL SFKSSVRCFT RTMSAMVMDD FEERRNADES
RITFLKGEKV KNCTVHVHDD SVFEPEEEFQ VHLGTPLGDH WSGAMVGVND IVTITITNDE
DAPTIEFEQA SYQVREPPGP DGIEVLNIKV IRHGDLDRTS KIRCSTRDGS AQSGVDYNPK
SRVLKFTPGM DHILFKVEIL SNEDREWHES FSLVLGPDDP VEAVLGEITM ATVTILDQEA
SGSLILPAPP IVVSLADYDH VQEVTKEGSK KTPSPGYPLV CVTPCDPHYP KYSVMKERCE
EAGINQTQVH FSWEVAAPTD TSGARSPFET VTDTTPYTSV NHMVLDSIYF SRRFHVRCVA
QARDKAGHLG TPLRSNIATI GTEGSICHTP VTTGTARGFQ AQSFIATLKY LDVKHKEHPN
RIHISVQIPH QDGMLPLIST MPLHNLHFLL SESIYRQQHV CSNLVTLKDL QGISETGFLD
DVSYDSISLG PGYDRPYQFN PNIREAKSIQ LYKHLNLKSC IWTFDAFYDM TELIDVCSGS
VTADFQVRDS AQSFLTVQVP LYVSYIYVTA PRGWASLEHH TEMEFSFFYD TVLWRTGIQT
DSVLSARLQI IRIYIREDGR LVIEFKTHAK FRGQFVLEHH TLPGHKSHLM APDHLGGIEF
DMQLLWSAQS FDSPYQLWRA TSSYSRKDYS GEYTVFLIPC TVQPTQPWID PGDKPLSCTA
HAPEKFLVPI AFQQTNRPVP VVYSLNTEFQ LCNNEKVFMM DPASADVSMA EMDYKGAFSM
GQTLYGRVLW NPEQNLNAAY KLQLEKVYLC TGRDGYVPFF DPTGTLYNEG PQYGCIQPNK
HLKHRFLLLD RKQPDVCDKF FHDVPFEAHL ASDLPELQTM TSMPGVDGFT MKVDALYKVE
AGHQWYLQVI YVISPESRSS PRIQRSVTYQ LSRPKRDLVD RSGRLTLDES LIYDNEGDQV
KNGTNMKSLR LEAGPSATFN AHVGSSVGGG VAAVTLLVLV LLAACLVFRR CRRSSAKKKG
KKAAKTYEEY PLNTKVEVCM DKCVEKNFST KHCTVRNINL LNRNQEPNGK AKVKQVNLEV
KLHNNLSDGT EV
//
