ID A0A3P8TYJ8_AMPPE Unreviewed; 764 AA.
AC A0A3P8TYJ8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=TLE family member 3, transcriptional corepressor a {ECO:0000313|Ensembl:ENSAPEP00000030184.1};
GN Name=TLE3 {ECO:0000313|Ensembl:ENSAPEP00000030184.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000030184.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000030184.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000030184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR AlphaFoldDB; A0A3P8TYJ8; -.
DR STRING; 161767.ENSAPEP00000030184; -.
DR Ensembl; ENSAPET00000030989.1; ENSAPEP00000030184.1; ENSAPEG00000021401.1.
DR GeneTree; ENSGT01030000234519; -.
DR OMA; NHHDLEL; -.
DR Proteomes; UP000265080; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 18..136
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 564..605
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 606..647
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 133..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 144..158
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 82522 MW; 9B8AAFD93D6C6A19 CRC64;
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
YVMSLSVSYF TISFSSPFVF QTEIAKRLNA ILAQIMPFLS QEHQQQVAQA VERAKQVTMT
ELNAIIGQQQ LQAQHLSHAA HGPPVQLPPH PSGLQPPGIP PVTGSGSGLL ALGALGSQAH
LPVKDEKNHH DLEHRGEEST SNNSISPSES LRTASEKHRS SSDYSLDSKK RKVEEKDSMS
RYDSDGEKSD DLVVDVSNED PATPRASPAH SPPENGIDKP RPPKKDTPNS PASVASSGST
PSSKAKELSH NDKSSTPGLK SNTPTPRNDA PTPGTSSTPG LRPILGKPPG MEALAAPALR
TPLSIAGSYP TPFAMMGHHE MNGGLTSPGV YAGLHISPQM SAAAAAAYGR SPMGFDPHTH
MRAPGLPASL TSISGGKPAY SFHVSADGQM QPVPFPPDAL IGPGIPRHAR QINTLSHGEV
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPVSQLDC LNRDNYIRSC KLLPDGRTLI
VGGEASTLTI WDLASQTPRI KAELTSSAPA CYALAISPDA KVCFSCCSDG NIAVWDLHNQ
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC
PTGEWLAVGM ESSNVEVLHH SKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR
TPYGASIFQS KESSSVLSCD ISTDDKYIVT GSGDKKATVY EVIY
//
