ID A0A3P8TZF7_AMPPE Unreviewed; 683 AA.
AC A0A3P8TZF7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000030494.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000030494.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000030494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3P8TZF7; -.
DR STRING; 161767.ENSAPEP00000030494; -.
DR Ensembl; ENSAPET00000031308.1; ENSAPEP00000030494.1; ENSAPEG00000021666.1.
DR GeneTree; ENSGT00940000164418; -.
DR OMA; CSEEHGY; -.
DR Proteomes; UP000265080; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF308; DELTA-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..683
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018103614"
FT TRANSMEM 517..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..202
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 203..236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 269..307
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 309..345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 347..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 386..422
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 424..460
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 462..498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 173..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 193..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 226..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 335..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 374..383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 412..421
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 450..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 683 AA; 74107 MW; C9746237A4336AAF CRC64;
MARLFLPCLL LLVAAQTALS SGVFELKIDS FTSSRGICRF QSQDCQIFFR VCLKHSQHVI
NPEPPCTYGT ALTEIFGADS NSISGSAPIR VPFHFKWPGT FSLIIEAWNA ESSGLESTEN
QNNLISRLAT RRKLMVGEEW SQDVGFGNQS ELRYSYHVVC NEFYHGEACS AYCRPRNDTF
GHYTCDDDGN RHCLEGWRGE YCSDPICAVG CSEEHGYCES PGECACRQGW QGEHCEECAR
HPGCLHGTCQ QPWQCHCKEG WGGLYCDQDL NYCTNHKPCQ NGASCTNTGQ GSYTCTCRPG
FTGKNCEIET NECDSNPCKN GGSCKDLEND YSCACPQGFY GKNCEISAMK CADGPCFNRG
TCVEKSTGGY TCRCPATYTG SNCEKRVDRC SSNPCANGAQ CLDLGNRVMC RCRPGFSGSR
CETNIDDCSS NPCRNAGTCV DGINDFSCTC TLGFTSKDCS VRTSACDQFP CDNGGTCFTH
FTGPVCQCPP GFMGARCEYP VAASTAKPPR SDDSPPALIA AVALGLVTLS LLLCAAVHIL
RQLRRSRELA AIASSVKNDL ETVNNRNAVI GGGGPNNGGL PGAPLGSLKE KEALLIPGGH
LKVSNKDAAL VDKGGDNVSM FKNKMADCNL AKEEQRLDKN KFDLKKCDSS IIVPPLSFAK
DSLYHSVFII PEQMEQCVFA TEV
//