ID   A0A3P8U0P4_AMPPE        Unreviewed;      1001 AA.
AC   A0A3P8U0P4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=SUMO-activating enzyme subunit 1 {ECO:0000256|ARBA:ARBA00044187};
DE   AltName: Full=Ubiquitin-like 1-activating enzyme E1A {ECO:0000256|ARBA:ARBA00044354};
GN   Name=UBA6 {ECO:0000313|Ensembl:ENSAPEP00000028862.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000028862.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000028862.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000028862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein sumoylation.
CC       {ECO:0000256|ARBA:ARBA00004718}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBUNIT: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds
CC       to the two domains that are encoded on a single polypeptide chain in
CC       ubiquitin-activating enzyme E1. Interacts with UBE2I.
CC       {ECO:0000256|ARBA:ARBA00026003}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC       {ECO:0000256|ARBA:ARBA00005673}.
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DR   AlphaFoldDB; A0A3P8U0P4; -.
DR   STRING; 161767.ENSAPEP00000028862; -.
DR   Ensembl; ENSAPET00000029622.1; ENSAPEP00000028862.1; ENSAPEG00000020511.1.
DR   GeneTree; ENSGT00940000158826; -.
DR   OMA; WSHCVEL; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265080; Chromosome 3.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd01491; Ube1_repeat1; 1.
DR   CDD; cd01490; Ube1_repeat2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR   Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR   Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR   Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR   Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR   InterPro; IPR032420; E1_4HB.
DR   InterPro; IPR032418; E1_FCCH.
DR   InterPro; IPR042302; E1_FCCH_sf.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR018965; Ub-activating_enz_E1_C.
DR   InterPro; IPR042449; Ub-E1_IAD_1.
DR   InterPro; IPR038252; UBA_E1_C_sf.
DR   InterPro; IPR019572; UBA_E1_SCCH.
DR   InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   InterPro; IPR018075; UBQ-activ_enz_E1.
DR   InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR   NCBIfam; TIGR01408; Ube1; 1.
DR   PANTHER; PTHR10953:SF162; SUMO-ACTIVATING ENZYME SUBUNIT 1; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF16191; E1_4HB; 1.
DR   Pfam; PF16190; E1_FCCH; 1.
DR   Pfam; PF09358; E1_UFD; 1.
DR   Pfam; PF00899; ThiF; 2.
DR   Pfam; PF10585; UBA_E1_SCCH; 1.
DR   PRINTS; PR01849; UBIQUITINACT.
DR   SMART; SM00985; UBA_e1_C; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          868..990
FT                   /note="Ubiquitin-activating enzyme E1 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00985"
FT   REGION          979..1001
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1001 AA;  111900 MW;  E976F3B7D6A58BE6 CRC64;
     MHQMAQSSVF LSGMGGLGVE IAKNIVLAGV KAVTLHDTKQ CETWDLGSNF FIRKEDVVSQ
     RRRVEAVSPR VAELNPYVHV DTCSSALDDN TDLSFLRKYQ CVILTEARLS LQKRVNEFCH
     SQQPPIRFIG CDAYGICVRV FCDFGGEFEV SDPTGEEPKE IFIQSITQDS PGVVTCMDNQ
     PHGLQTGQSV VFREVNGMME LNSTARQVSV LSPHSFAIGD TSQLQPYAHG GFFVLVKTPK
     TYKFETMEQQ LCDPQVLTPD FSKPEAPLQI HAAMFALDTF QEQHSRLPNI GCLQDAEALL
     KLTEEVNATL KSKTPVNTEL VRCLSRTARG TLPPLAAAVG GVASQEVLKA ITGKFAPLQQ
     WLYLDAIEVV RPLQSLSAED FFPRGDRYDG LRACVGESMC LELHKLRVFM VGCGAIGCEM
     LKNFALLGVG LTKSSGEVCI TDPDLIEKSN LNRQFLFRPH HIQKPKSTTA AEATHDINPD
     LQVDAHLNKV CPATENIYSD SFFTSLNLVV TALDNVEARR YVDSRCVSNQ RPLLDSGTMG
     TKGHTEIIVP NLTESYNSHR DPPEEEIPFC TLKSFPSVIE HTIQWARDKF ENAFVHKPSM
     YSSFWQTHSS AEVVLQRMQA GESLEGSFQV IKLLSRRPSQ WEQCVTIARL KFEKYFKRKA
     LQLLHSFPLD TRLKDGSLFW QSPKRPPAPI DFDLNDSLHF TFIVSTARLF AGIYNIPYSE
     TDLSEEAVTR ILSDVKIPEY KPSEKCIETD ETAKKPDQMK MPVSSEEERE AIIQLEQAIA
     TDRVTPEGLQ MTPLQFEKDD DSNGHLDFVT SASSLRARMY SIEPADRLKT KRIAGKIIPA
     IATATAAVAG LVALELIKVV GGYGFESFKN CFFNLAIPVV VLTEPAPVKQ TLIRNNIYFS
     IWDCWTIFGH EDFTLSDFMN AVREKYGIEP TMVVHGVKML YVPVMPGHSK RLKLTMQKLI
     KPSVDRRYVD LTVSFAPEAD GDEDLPGPPV RYYFSPDGET P
//