ID A0A3P8U122_AMPPE Unreviewed; 611 AA.
AC A0A3P8U122;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial {ECO:0000256|ARBA:ARBA00013888};
GN Name=NDUFS1 {ECO:0000313|Ensembl:ENSAPEP00000032225.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000032225.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000032225.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000032225.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 75 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005404}.
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DR AlphaFoldDB; A0A3P8U122; -.
DR STRING; 161767.ENSAPEP00000032225; -.
DR Ensembl; ENSAPET00000033082.1; ENSAPEP00000032225.1; ENSAPEG00000022881.1.
DR GeneTree; ENSGT00940000153514; -.
DR OMA; QDQAMAY; -.
DR Proteomes; UP000265080; Chromosome 12.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd02773; MopB_Res-Cmplx1_Nad11; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.200.210; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR010228; NADH_UbQ_OxRdtase_Gsu.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR InterPro; IPR015405; NDUFS1-like_C.
DR NCBIfam; TIGR01973; NuoG; 1.
DR PANTHER; PTHR43105:SF13; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR Pfam; PF09326; NADH_dhqG_C; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00642; COMPLEX1_75K_2; 1.
DR PROSITE; PS00643; COMPLEX1_75K_3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 1..31
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 129..185
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 611 AA; 66516 MW; E0DBE7BE0E21E461 CRC64;
MEFLLANHPL DCPICDQGGE CDLQDQSMQF GSDRSRFTEG KRAVEDKNIG PLIKTIMTRC
IQCTRCVRFA SEIAGVEDLG TTGRGNDLQI GTYVEKMFMS ELSGNVIDIC PVGALTSKPY
AFTARPWETR KTETIDVLDA VGSNIVVSTR GGEVMRILPR LNEDINEEWI SDKTRFAYDG
LKRQRLTQPM VKNESGQFVP TSWEDVLTRA AGALQGVEGN DVAAVVGGMV DAEALISLKD
LLNRLNSENL CTEEVFPMNG AGSDLRSNYL LNTGIAGIEE ADLLLLVGTN PRYEAPLFNA
RIRKSWLHNE LQVALVGKEV DVSYTYDHLG ESAKILQEIA SGTHPFSQVL AKAKHPVVVA
GSSCLQREDG AAILAAVSTI AQNARVSSGV DETWKVLNVL HRVASQVAAL DLGYKPGVEA
VRKNPPKVLF LLGADSGCIT RQDLPKDSLI IYQGHHGDVG APMADIILPG AAYTEKCGTY
VNTEGRAQQT KVAVTPPGMA REDWKIIRAI SELAGVTLPY DTLDEVRDRL AEVSPNLVRY
DDVEEANYFK QANELSKAVD QGVLTEPLVP PQLTVKDFYM TDPISRASQT MAKCVKAVTE
GAQAVDEPAI C
//
