ID A0A3P8U135_AMPPE Unreviewed; 663 AA.
AC A0A3P8U135;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSAPEP00000030561.1};
GN Name=NEFH {ECO:0000313|Ensembl:ENSAPEP00000030561.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000030561.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000030561.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000030561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8U135; -.
DR Ensembl; ENSAPET00000031379.1; ENSAPEP00000030561.1; ENSAPEG00000021319.1.
DR GeneTree; ENSGT00940000161893; -.
DR Proteomes; UP000265080; Chromosome 5.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 58..359
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 253..333
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..450
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..526
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 75649 MW; A2A710DFF0F24204 CRC64;
MSFTVEHHFM GPGSYRKARP ASVSSSGFHS QRRRHTYSQP SSIDSLETFN GDMTRRSEKE
ILQALNDRFA GYIEKVRNLE MHNRNLEAEA AALRQSQAGR ASVGEHYERE LCDLRDLLQQ
LTGEKARAAL EHEHLEEDIQ HLRVRLEDEA RNREELEAGV RTMKKYVEEC RLARLELDKK
MCALEEEAAF LKKNHEEEVA ELLAQIQGAQ VSFDMRDALK ADVTSALREI RSQLDTHASK
SSTHAEEWFK VRMERLSEAA RSNQNAIRGS QEEIAEYRRQ LQSRTIELET LRGMKESLER
QRMESEDRHQ DDLNSLQETI NQLDNELKTT KWEMASQLKD YQELLNVKMA LDIEIAAYRL
VRAKKHTYLN CLIEVTEEAD DEEEVEEEKH EEAGEAEEEG EETKEEGEGE GEEGENKEEE
GEEEKEEEKG EEEKEEGEEK GDEEEAGEEE EKSKSPEKAA SPPSKSPQPK SPVVKSPESK
SPQKSPESTS PAAKSPMPKS PAKSPSPVSK SPPSKSPEPK SPPPKTPEPK SPEKEVAKPV
AAKDTPKEEK KEEKKEEKPQ PEKEEKKEKE QPVKEEKKEE PKEKEVAKPD TKKDKAKPEE
KKPEEKPAPK VEPEKTETKK EEKKPEEKKE ASKAESKEAA KMEKAEKSSG TESKESKEEK
AKK
//
