ID A0A3P8U2C8_AMPPE Unreviewed; 432 AA.
AC A0A3P8U2C8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000031469.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000031469.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000031469.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8U2C8; -.
DR STRING; 161767.ENSAPEP00000031469; -.
DR Ensembl; ENSAPET00000032302.1; ENSAPEP00000031469.1; ENSAPEG00000022346.1.
DR GeneTree; ENSGT00950000183127; -.
DR Proteomes; UP000265080; Chromosome 6.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR PANTHER; PTHR19944:SF106; DLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN-LIKE-RELATED; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 2.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 2.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00290; IG_MHC; 1.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..432
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017998111"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..195
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 298..387
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 432 AA; 49235 MW; 9029403E3B3EFEF4 CRC64;
MALSAIILLI STGAASATTS SHQFHYIYSC YESNNVGVDV VFDDVVIAYA DFNKEEMVMA
VPELPKSIMQ WKKRAYEIAK TSIAHCHRTL TTAKGADPGS PMRQEAPDSF VYTRYEGEEN
VVNTLYCLAK HFYPPTINFT WTKNGVEVTE GVFNLRYQHN DDGTFHRIST LTFTPQEGDV
YSCKVEHQAS QQPLTRTWDC SADEDGYFMY ADFWCSMHSR KKEQVEYLVD WYFNKEFTMN
YNSTVGKWTG LTPAGGITAS AHNNNKHDLL QRKVERQLIC VDNVELIYNV TEEYMAEPSL
SLQEVDDASG HVATLVCSAY DFYPKYIKVM WHRDGQEVTE GVTVSEVMTN GDWTYQVHSY
LEYTPGRRDQ ISCMVEHATL SEPKILHWDL SLDRSTKSFL AGGVCALLLG AIFLSFGLTR
YWRKSQQLSN VL
//
