ID A0A3P8U2G3_AMPPE Unreviewed; 854 AA.
AC A0A3P8U2G3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily B member 2 {ECO:0000313|Ensembl:ENSAPEP00000031041.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000031041.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000031041.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000031041.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8U2G3; -.
DR STRING; 161767.ENSAPEP00000031041; -.
DR Ensembl; ENSAPET00000031865.1; ENSAPEP00000031041.1; ENSAPEG00000022048.1.
DR GeneTree; ENSGT00940000161902; -.
DR OMA; PCKGGVN; -.
DR Proteomes; UP000265080; Chromosome 22.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18412; BTB_POZ_KCNB2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003973; K_chnl_volt-dep_Kv2.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF134; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03521; Kv2channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01495; SHABCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..145
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 95305 MW; CB158CBF960F2570 CRC64;
MAEKLGQAGL KPTNIRTAPP LPPEPIDIIR TKARSRRVRL NVGGLNHEVL WRTLDRLPRT
RLGKLRECNT HESLMEVCDD YSLNENEYFF DRHPGAFTSI LNFYRTGKLH MMEEMCALSF
GQELDYWGID EIYLESCCQA RYHQKKEQMN EELRREAETM REREGEGEFD NTCCPDKRKK
LWDLLEKPSS SVAAKILAII SILFIVLSTI ALSLNTLPEL QVIDEFGQAN DNPQLAHVEA
VCIAWFTMEY LLRFLSSPNK WKFFKGPLNV IDLLAILPYY VTIFLTESNK SVLQFQNVRR
VVQIFRIMRI LRILKLARHS TGLQSLGFTL RRSYNELGLL ILFLAMGIMI FSSLVFFAEK
DEDATKFTSI PASFWWATIT MTTVGYGDIY PQTLLGKIVG GLCCIAGVLV IALPIPIIVN
NFSEFYKEQK RQEKAIKRRE ALERAKRNGS IVSMNLKDAF ARSMELMDVV VEKGEDKTSL
DNHLSPNRWG SSTRHAASET NLKSPDKRNP QSQNSPHRIT ITTTGSPQRT SRTPQHLNVQ
KLEEMYNQMT KSQSFTNLNT ASSMSTLSTT MTAPASPKKS YSPELTLKEE VELEMKEVQP
SSGNNFASCS ADLTKQSSNS DEEDAGPCQI RHPRAPPPLD LRQLRDGQSS PGIILKDGLY
QPVNPDDGSV LHIEEGESFN SAVEHIQSSI RGNNPLKIKG LKVNLNKTSA DCPLTPPSTT
SPGDISSSIL EDESPEGETS PLIPSSEELL PVTAEDSCPL SPKRLMVDTP PGDEDQSTEN
HEEKHLMEVA GAAVAPLSPK TAAQNCTQGV VGAGEEVKAD SNQSGHKVEN HMFTSDIHLI
PGDGSLSPTC ETSM
//
