ID   A0A3P8U3L9_AMPPE        Unreviewed;       373 AA.
AC   A0A3P8U3L9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Anti-dorsalizing morphogenic protein {ECO:0000313|Ensembl:ENSAPEP00000031924.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000031924.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000031924.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000031924.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; A0A3P8U3L9; -.
DR   STRING; 161767.ENSAPEP00000031924; -.
DR   Ensembl; ENSAPET00000032771.1; ENSAPEP00000031924.1; ENSAPEG00000022668.1.
DR   GeneTree; ENSGT00940000165063; -.
DR   OMA; DRLQPCQ; -.
DR   Proteomes; UP000265080; Chromosome 10.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13765; TGF_beta_ADMP; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF241; ANTI-DORSALIZING MORPHOGENETIC PROTEIN; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..373
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018238512"
FT   DOMAIN          254..373
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   373 AA;  41976 MW;  5725C607202274FC CRC64;
     MLMFVISVAT FVCTSTARPS ENYPENRFTA ENESQEVRSA AIKRLLEVFG MDDPPAIHGH
     KQPPQYMLDL YNTVAGRCDQ RPVSSGGEYL RSEQVEFSFN LSTVARTEKI LTAELHLFKL
     RPQGSFNRHH FCQVSVYQLL DSSKTNNTQE KKLLSSRLIP IHSTGWEVFT VTQAVRSWMM
     DEGNNLGLHV VVRTLGGSQI DMKLIRFASG RSHHQSKQPM LVLFTDDGRH SAPLESKGQI
     FVNFNAPRSG PSSRSTRSLD YSEEEGVSMP CQRQPLYVDF EEIGWSGWIV SPRGYNAYHC
     KGSCPFPLGQ NMRPTNHATV QSIINALKLI KGIETPCCVP DKLFSINLLY FDDDENVVLK
     QYNDMVAGSC GCH
//