ID A0A3P8U3N3_AMPPE Unreviewed; 330 AA.
AC A0A3P8U3N3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hes related family bHLH transcription factor with YRPW motif like {ECO:0000313|Ensembl:ENSAPEP00000029913.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000029913.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000029913.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000029913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P8U3N3; -.
DR STRING; 161767.ENSAPEP00000029913; -.
DR Ensembl; ENSAPET00000030713.1; ENSAPEP00000029913.1; ENSAPEG00000021251.1.
DR GeneTree; ENSGT00940000166437; -.
DR OMA; GQEDGFC; -.
DR Proteomes; UP000265080; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF140; HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 42..97
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 118..149
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 35056 MW; 4F0B49E3D83988D7 CRC64;
MKRPHDYSSP DSDTDEFIDV GQEDSYPVTG SMSPGSASQI LARKKRRGII EKRRRDRINH
SLSELRRLVP SAFEKQGSSK LEKAEILQMT VDHLKLLHAM GGKYFDARAL AVDYRTLGFR
ECVGEVVRYL SSLEGESPDP IGARLVSHLS HCASELDPLL LQSPPASTLP FPPWPWASFP
QISPTSPASS SPPFPGGRRD LALLGSYPSP ASLRLAPLAG CQQGAPPLLA PTALATVHRV
PSLTASPSLT PSRPTQPSPH STTRASPLPL PTPSSSSPST SSSSATSSSA APPQVSFRPF
APLGSPTVQR RGLSGSAKAA QGWGTEIGAF
//
