ID A0A3P8U460_AMPPE Unreviewed; 995 AA.
AC A0A3P8U460;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSAPEP00000033310.1};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSAPEP00000033310.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000033310.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000033310.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000033310.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8U460; -.
DR Ensembl; ENSAPET00000034184.1; ENSAPEP00000033310.1; ENSAPEG00000023591.1.
DR GeneTree; ENSGT00940000157711; -.
DR OMA; XFSELLN; -.
DR Proteomes; UP000265080; Chromosome 22.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 21..73
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 95..214
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 150..213
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 218..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 766..800
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 224..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 102824 MW; D89B7FFF0B8B3BA7 CRC64;
MVSGERCLAA EFSTSNMKEM IGGCCVCSDE RGWAENPLVY CDGHGCNVAV HQACYGIVQV
PTGPWFCRKC ESQERAARVV SISPGVSGHV PKSGRLRCEL CPHKDGALKR TDNGGWAHVV
CALYIPEVEF ANVSTMEPIV LQSVPHERYN KTCYICEDQG RESKAATGAC MTCNKHGCRQ
AFHVTCAQFA GLLCEEQGSD ADNVKYCGYC KYHHSKLRRS RGRGSRSQSI SDSSSQCMDR
PPDQDKKKHK ERDRHKPRHK KTPMDMSPSL VLPNIMVPEK TYNSGNSGGG VTSLPASSQK
RLDDSSGRFT NANFQEVSSA HSGGGSKDAL AADTGKVASE VKNKKNSGGG HAVGQRGGRK
SLTSSGKPLP SAVVTMATSS TSASASTGPF HQGLLLTSAS KTASAPSSSD FLSFSDSSLR
PGGGTTFSSP PSFSSCLVKP SSEGGASEGT TTLFGSLMSA TSASAVGGKL YENSHSHTAS
ETTSLVGSTG YKRPQPSSAG LGIGAAAAGA GEDGVKKKKK GNWRNRFGPC FTTDVKPSEP
APSLTLPTSS TANTSSSTAS PSSSSSTALS GRGLGVMGVS SGIQKSPSLL RNGSLQSSSS
SIATGSASSE LSQQQQPTPS LAPPSPFTAT APLNSTASTH VSGLPGSVFN LAPPHMFGNR
LNPNSTMAAL IAQSEASPAD SSGGVGAQGF SIRASPKTTP RSPIGGLQIR YDSSGSLPGP
GLGLLGAGGG GTETLPPVAT SIEQLLERQW NEGQSFLLQQ GAQGDVVGML KSLHQLQEEN
RRLEEQIKTL TMKKERLQLL SAQLSVPFTP STTSSGIHTH THTHTHTHTH THTCALELKS
QLGATDSSLP VAAQDSASCG GHSSSGSTSS LSTPPSVSQS PPQPQINGVA TVGATPAGLG
GVAGLMGALG AGSALGMGGI VGALNGVIQT PAGTASPHTH TTGAATGVTL QHRFLLQQQQ
HQLQQLLSSQ PSAVRRTRVN THTHARTHAH TAANM
//
