ID   A0A3P8U557_AMPPE        Unreviewed;       777 AA.
AC   A0A3P8U557;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Transferrin receptor 2 {ECO:0000313|Ensembl:ENSAPEP00000033670.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000033670.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000033670.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000033670.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC       protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   AlphaFoldDB; A0A3P8U557; -.
DR   STRING; 161767.ENSAPEP00000033670; -.
DR   Ensembl; ENSAPET00000034551.1; ENSAPEP00000033670.1; ENSAPEG00000023927.1.
DR   GeneTree; ENSGT01030000234598; -.
DR   OMA; QVVFNNH; -.
DR   Proteomes; UP000265080; Chromosome 23.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd09848; M28_TfR; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   PANTHER; PTHR10404:SF33; TRANSFERRIN RECEPTOR PROTEIN 2; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          226..289
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          398..574
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  85208 MW;  4ACDAB96CC7F6040 CRC64;
     MTTHSTQCSS ATLRHSLSDD DEMGGAQGVE LRLVTSEEDE TEAGPISDVT ALVLRHRHGY
     RRAGMLLCAC GVIVFTAAFL LAYGVLSGRY HCSQSGDQDE EQQRGGANSL AGGGAGLYLG
     ELRVMMRRLL QDEDIHNTVS RVSRAPHPPG SSEGTALASE ILHRFQQLQM DHTWTESLYA
     TLQFPDRTQR SSLRLVDSAG LILEQISLNL SDFCPYSATG TTMGGVVYAN YGRQADFNWL
     KSAGVSVTGC VVVMRVGGGV SFAEKVWLAE RNGAGGVLIY PDPADLPQDP RRLGLNTHTA
     VSEHVHLGSG DPFTPGFPSF NHTQFPPIQS SGLPFIPALP ITATIAAKLL SQLSGASCPP
     SWRGRLPYVR CVVGPELNAG RRVQLSVHNK MMPILLNNIF SSLEGRVEPD QYIILGAQRD
     SLGPGAVKSG VGTAILLELA RTFSVMVKNG FNPRRSLLFV SWDAGEFGNV GATEWLEGYL
     SMLHLKAVAY FSLDQAIMGD DVLSAYTSPL LVDLLEAAIR QVEHPKHAGQ TIYSQAEREG
     GSWRIVKPLY LNSGAYSFTA FAGVPAMELR FTEERAYPFV NTPLDSASRL QEVLGGRLGV
     TGRSVGELVG EMVLRLAHDH ILPLRITSYA QTVLQFSAQL NRHSAELQSR GLSPQWVFSA
     RGDYSRAAEM LQRAIDYSDL HDPTTARFYN TRIMKVEYYF LSQYVSAVET PFRHVIHGRG
     NHTLSALTEH LGLLTSDPKR FDERRFRRQL ALFTWTLQGA ANALNGDVWR VHNAHSH
//