ID A0A3P8U595_AMPPE Unreviewed; 178 AA.
AC A0A3P8U595;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Endothelin-1 {ECO:0000256|ARBA:ARBA00040197};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000030483.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000030483.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000030483.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
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DR AlphaFoldDB; A0A3P8U595; -.
DR STRING; 161767.ENSAPEP00000030483; -.
DR Ensembl; ENSAPET00000031297.1; ENSAPEP00000030483.1; ENSAPEG00000021668.1.
DR GeneTree; ENSGT00950000183053; -.
DR OMA; EKWPARR; -.
DR Proteomes; UP000265080; Chromosome 17.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF10; ENDOTHELIN-1; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..178
FT /note="Endothelin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018060204"
FT DOMAIN 45..66
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 99..120
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
SQ SEQUENCE 178 AA; 19982 MW; 744F9FA621FB64DA CRC64;
MDLYVFISVL SVMFPWISCT ALPAPVADAP TASTGNLRHR VRNKRCSCAT FLDKECVYFC
HLDIIWVNTP ERVVSYGLGN APRTRRALAD SMATSGAPRC RCLRENDATC GTFCGNRKYD
STEIRSPEGR QQPAADSIRR LAGNRVSPVA QKTRLLLEKW RVRQRHRVRA WEGHGSAS
//
