ID A0A3P8U5M4_AMPPE Unreviewed; 994 AA.
AC A0A3P8U5M4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSAPEP00000032126.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000032126.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000032126.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000032126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8U5M4; -.
DR STRING; 161767.ENSAPEP00000032126; -.
DR Ensembl; ENSAPET00000032979.1; ENSAPEP00000032126.1; ENSAPEG00000022667.1.
DR GeneTree; ENSGT00940000156299; -.
DR Proteomes; UP000265080; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032506; P:cytokinetic process; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR CDD; cd01229; PH_Ect2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR026817; Ect2.
DR InterPro; IPR049396; ECT2_BRCT0.
DR InterPro; IPR049395; ECT2_PH.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF21243; ECT2_BRCT0; 1.
DR Pfam; PF21242; ECT2_PH; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265080}.
FT DOMAIN 172..251
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 267..355
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 483..672
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 390..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..968
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 112591 MW; 38671825F2372758 CRC64;
MADSSIVTLG TARSLLVDSS VYDSRIAETT KDHVFLGMTC EDGEDMLPKV ETRVVLVGEA
GRNGALVKAL QAIRVMEVPV VKIKEGEAGT EEKMMIKSIV NMDINTPFIM TDNVQEFADG
ENTDFETVFV LKDFDSPDYS YLYKRDNRIV GPPVVLHCAA KEEPLHFSCR PLYSTTMLNV
SLCFTGFRNK EEMKNLVNLV HHMGGTIRKD FSTKVTHLIA YSTHGEKYRL AVCMGTPILT
PSWIHKAWER RDDVHFHAGE EEFRTEFKVP PFQDCILSFL GFSEEEKTNM EERTLKHGGG
YLEVGDERCT HMVVEENSVK ELPFTPSKKV FVVKQEWFWG SIQMDARAGE SMYLYEKNDS
PAMKKAVSLL SLTTPNSNRK RRRLRDTLAQ LTKETEISPF PPPRKRPSAE HSVSIGSLLD
ISNTPETYNT VTRNKIRRKK TRERRSRTDR EERRKRSHPR TYQPGEDSKP SKSSTPVLSK
QSARWQVSKE LYQTESNYVD ILSTILQLFK LPLEKEGQVG GPILAQEEIK TIFGSIPDIY
EVHTRIKNDL EELLSDWSES RSVGNIILKY SKELVKAYPP FVNFFEMSKE TIVRCEKQKP
RFHAFLKINQ AKPECGRQTL AELLIRPVQR LPSVALLLND IKKHTSDDNP DKITLEKAIE
SLKEVMTHIN EDKRKTEGQK QIFDVVYEVD GCPANLLSSH RSLVYRVETI ALGDQPCDRG
EHVTLFLFND CLEIARKRHK VINTFKSPLG QTRPPPPLKH IALMPLSQIR RVLDLQDTEE
CVNAFALVVR PPTEQENLLF SFQLTGEETV KSAWLRTLCR HVANTICRAD AEDLIQCTDP
DSLQVSTKDM DSTLSKASRA IKKTSKKVTR VFSFTKTPKR AIQRAFLANS TPDEKSQRLS
IENRVGSSST LAMSRSASTF SLSDSAKGSA MVQRSNSLDH PPVRARVPVS MRPPYSPVPN
PAPEYNPSLT QSPQPQSRVT PLVSFASTAT NSKT
//
