ID A0A3P8U8Z3_AMPPE Unreviewed; 943 AA.
AC A0A3P8U8Z3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Solute carrier family 8 member 1a {ECO:0000313|Ensembl:ENSAPEP00000031823.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000031823.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000031823.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000031823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3P8U8Z3; -.
DR STRING; 161767.ENSAPEP00000031823; -.
DR Ensembl; ENSAPET00000032666.1; ENSAPEP00000031823.1; ENSAPEG00000022587.1.
DR GeneTree; ENSGT00940000155129; -.
DR OMA; MEVANYQ; -.
DR Proteomes; UP000265080; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878:SF69; SODIUM CALCIUM EXCHANGER 1H; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..943
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018323416"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 384..484
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 510..610
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 943 AA; 104829 MW; 87874521957CBB17 CRC64;
MISRFSTYQL LLLLTVFSSE FPHPAAGSSN TTLTNRTKCG GSTDCIEGVI LPVWKPDNPA
FTDRLARATI YFVGLVYMFL GVSIIADRFM ASIEVITSQE RRITIKKPNG EKVTTMVRIW
NETVSNLTLM ALGSSAPEIL LSVVEVCGHN FDAGELGPNT IVGSAAFNMF VIIGLCVSVI
PEGETRKVKH LRVFFITATW SVFAYIWLYL ILAVISPGVV QIWEGLLTLF FFPLCVGFAY
VADRRLLFYK YMYKRYRAGK QKGMIIETEG EPELPSKVDI EMDGKMLNSH GEEFLDGEAG
FEEKELDEEE SRREVAQILK ELKQKHPEKE MEQLMELANY QVLMQQQKSR AFYRCQATRI
MTGAGNVLKK HAADQAKRAT QLNLSSEVSA NDFSSKVFFD PGTYQCLENC GSVLLNVVRR
GGDLTSTVAV DYRTQDGTAN AGSDYQFTEG TVVFKPGETE KEICIDIIDD DIFEEDEHFL
VHLSNVKVVS EDQRANHVDT LAGLGLPCTA TVTIFDDDHA GIFTFEEPVV RVSESVGVME
VKVVRTSGAR GVVVVPYKTM EGTAKGGGED FEDTHGVLEF ENDEILKTIQ INIIDDEEYE
KNKNFFLEIG EPQLLEMSQR KGVGACPVGV ALDVYRKVQG REHPATSTFI SITAEEVLTK
KEEEERRIAE MGRPTLGEHV KLEVIIEESY EFKSTVDKLI KKTNLALLIG TNSWREQFVE
AITVSSGDDN DDDECGEEKV PSCFDYVMHF LTIFWKLLFA FVPPTDYWNG WACFVVSISI
IGILTAVIGD LASHFGCTVG LKDSVTAVVF VALGTSVPDT FASKVAAIQD QYADASIGNV
TGSNAVNVFL GIGVAWSIAA IYHYIQGEEF KVDPGTLAFS VTLFTIFAFI CIAVLIYRRR
PEIGGELGGP RVPKILTTCL FFSLWLMYII FSSLEAYCHI EGF
//
