ID   A0A3P8U9X7_AMPPE        Unreviewed;       706 AA.
AC   A0A3P8U9X7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Si:dkey-49n23.1 {ECO:0000313|Ensembl:ENSAPEP00000032243.1};
OS   Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000032243.1, ECO:0000313|Proteomes:UP000265080};
RN   [1] {ECO:0000313|Ensembl:ENSAPEP00000032243.1, ECO:0000313|Proteomes:UP000265080}
RP   NUCLEOTIDE SEQUENCE.
RA   Lehmann R.;
RT   "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT   of the orange clownfish Amphiprion percula.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPEP00000032243.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|ARBA:ARBA00009492}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   AlphaFoldDB; A0A3P8U9X7; -.
DR   STRING; 161767.ENSAPEP00000032243; -.
DR   Ensembl; ENSAPET00000033101.1; ENSAPEP00000032243.1; ENSAPEG00000022875.1.
DR   GeneTree; ENSGT00940000165085; -.
DR   Proteomes; UP000265080; Chromosome 6.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF69; SI:DKEY-49N23.1; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..480
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   DOMAIN          534..610
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          686..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  80512 MW;  7FD9C44D75AA8C86 CRC64;
     HRETQNDDKD TQNRYTKLQR FPCVTLSVVL LIVVLCVPEL RNGSAVFWED GVSGGFQVLL
     LDEDQGWLLV GGKDHVYLLR PDGLDLKTRT VRRTQMLLLA VPLRTHETDC ANFVRLLQPF
     NKTHIYVCGT GAFHPQCSYL ELGPNAEVET SIIHPSILLL GCLSPEGELY AGTSVDFMGA
     NAAIFRTSIQ GSSQHYIRTE AYDHNWLNEP EFVGSFSIPD THSPDDDKVY FFFKERAVEA
     GQWDRRVYSR VARVCKNDVG GKRSLINRWT TFLKARLVCS VPGPSGVDTQ FDELEDIFVL
     ETKDPQNPTV YGVFSTSSSV FRGSAICVYS MASIRAAFNG PFAHKEGPDY RWVEYKGRIP
     YPRPGTCPSE TYDVLHKSTK DFPDDVISFM RQHQLMWEPV LPLGGRPVLT RVQQDYMLKK
     VVVDRVEAED GAYDMNGKVV KAVSVIKDSW NREEIILEEM SIFQQHLYVS SDVGVVQLSL
     HRCDFYGSDC AECCLARDPY CSWDGQTCSR FFPSSKRRAR RQDVKHGDPW SQCPITEDDS
     GSVEVKQVYG VEGNSTFLEC SSRSGKAEIR WTTLICWFGS DRGLLLQRLD PTDAGVYSCS
     AHEQNYVQLQ ARYRLHVLPQ HGLQPAGKLP GLQPGLQAHR NSWPNPLRSY KDLQMVDSLN
     MDQYCEQLWY REKRRQQKLR TLKLKQENRK ARVRRNNPPE RSGQEE
//