ID A0A3P8UD78_AMPPE Unreviewed; 354 AA.
AC A0A3P8UD78;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Homer scaffold protein 2 {ECO:0000313|Ensembl:ENSAPEP00000034806.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000034806.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000034806.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000034806.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; A0A3P8UD78; -.
DR STRING; 161767.ENSAPEP00000034806; -.
DR Ensembl; ENSAPET00000035715.1; ENSAPEP00000034806.1; ENSAPEG00000024715.1.
DR GeneTree; ENSGT00940000157324; -.
DR OMA; VHREITN; -.
DR Proteomes; UP000265080; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF2; HOMER PROTEIN HOMOLOG 2; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..110
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 112..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 159..318
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 40050 MW; CC4C0074CAA2683A CRC64;
MGEQPIYTTR AHVFQIDPTT KKNWVPASKQ AVTVSYFYDS TRNSYRIISV DGSKVIINST
ITPNMTFTKT SQKFGQWADS RANTVFGLGF ASEQQLTKFA EKFQEVKEAA KLARDKSQEK
VETLSNHSQE SGRETPTTNQ ASSINGTDDE KISHVGPEAA LLQTENERLK SVVEQSNTNA
KKWETELQTL RENNARLVDA LQESSANVES WKKQLSACKE ESDTLREKIA ELEAQCNEAN
QEKQKNAQLT VRVKELEAEL QDKEQELENL RKQAEIIPQL MAECESITTK LQAAEMKNKE
LEGRIEGLQL DIDDSRQKQG NMKGELKKFM DILDGKIDEL HEFRQGLSKL GVDN
//
