ID A0A3P8UF38_AMPPE Unreviewed; 1026 AA.
AC A0A3P8UF38;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSAPEP00000033922.1};
GN Name=TLR8 {ECO:0000313|Ensembl:ENSAPEP00000033922.1};
OS Amphiprion percula (Orange clownfish) (Lutjanus percula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000033922.1, ECO:0000313|Proteomes:UP000265080};
RN [1] {ECO:0000313|Ensembl:ENSAPEP00000033922.1, ECO:0000313|Proteomes:UP000265080}
RP NUCLEOTIDE SEQUENCE.
RA Lehmann R.;
RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome
RT of the orange clownfish Amphiprion percula.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPEP00000033922.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3P8UF38; -.
DR STRING; 161767.ENSAPEP00000033922; -.
DR Ensembl; ENSAPET00000034809.1; ENSAPEP00000033922.1; ENSAPEG00000024101.1.
DR GeneTree; ENSGT00940000160879; -.
DR OMA; LSWNCYF; -.
DR Proteomes; UP000265080; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1026
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018129483"
FT TRANSMEM 816..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 863..1007
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1026 AA; 117724 MW; 75BC9250245ECF8E CRC64;
MAVTCWMCLL LFCLCCHYEI QPAECKPTWM SRQFPCDVTA QNSSKVIFDC KGRHLHRVPD
GITSNATDLN LSENFIENIT ADSFSNLLNL TQLNLNWANK NKELIIAANA FKNLTKLHQL
RLSGICLKAI PSNIPSTVEI LELNINKIKM DNMSLTGLRN VTKLWLSRNC YMWNPCGRSV
TINDTSFLVM TKLQTLDLSF NNLTQVPKGL PPSLTELYLG SNKIEYIAAD HFCELHNLTM
LGLQGNCPRC QNAPFPCVPC QNGSLSIHPA AFQNLTRLKM LNLGGNSLQH LNPSLFERLS
NLKSLFLSFN FLLKTITDEA TFLRYLPRLE KIDLSFNFAL KFYPNTVNLS KEFSNLKSLR
TLHLEGLVFQ NIKPGTLKPL YELKNLSALN LGTNFIIHSD SIIFRKFHHL KMIYLAENKL
YPTPDPQHPS NRYNQRLDLS VSPIRKAHPK DSNYELSHRL IKQECFNAGR VLILSSNNLF
FISPKQFNSY GDIACLNLSG NGFSAAPNGT EFSQLPNLTY LDLSFNKIDL AYDDAFNELQ
KLQVLDISYN AHYFQAFGIT HNLHFTKNLP VLRVLNMSHN AISTLTTKQM YSQSLAELQF
THNHLGTLWK EKDGSYKTLF TNLTNLTLLD ISHNNIAKIP INVYECLPDK LITLHISHNS
LTEFAWDKLK HFYQLQILDL SFNSLSNVTG IDSSITNTLT FLDLSHNHIF HLDNGFIKGP
KSLTTLSLSY NKLTTINQST FLSGRENPIK TLFLQKNPFQ CKCDSLDFIL WIEDSNIKIP
RLTTEVTCDT PANQKSQILI DFDINQCVND SLACQIYIVT TFFIIVFMFV ATTAHLFYWD
ASYVLHYLKA KLKGYRSFYS SDSVYDVFVT YDTRDPHVSE WVMGNLRVKL EEEGEKHLPL
CLEDRDWPLG VPLVENLTQS IQYSRKTLFV LTESYVKTGA FKLAMYLAHQ RLLDENVDVI
VLLMLEPVLQ HSHFLRLRKR LCEKSVVEWP RTAAAEPWFW QNLRNVVRVD NQVMYNKSYS
KYFTSR
//
