ID A0A3P8UFD8_CYNSE Unreviewed; 2089 AA.
AC A0A3P8UFD8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Latent transforming growth factor beta binding protein 2 {ECO:0000313|Ensembl:ENSCSEP00000001122.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001122.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000001122.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000001122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 244447.ENSCSEP00000001122; -.
DR Ensembl; ENSCSET00000001150.1; ENSCSEP00000001122.1; ENSCSEG00000000780.1.
DR Ensembl; ENSCSET00000001169.1; ENSCSEP00000001141.1; ENSCSEG00000000780.1.
DR Ensembl; ENSCSET00000001198.1; ENSCSEP00000001170.1; ENSCSEG00000000780.1.
DR GeneTree; ENSGT00940000155823; -.
DR OMA; ADPPHCA; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000265120; Chromosome 1.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 17.
DR Gene3D; 2.10.25.10; Laminin; 24.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF111; FIBRILLIN-3; 1.
DR Pfam; PF07645; EGF_CA; 20.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 25.
DR SMART; SM00179; EGF_CA; 23.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2089
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040592015"
FT DOMAIN 183..215
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 420..452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 575..617
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 645..685
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 695..747
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 937..973
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 980..1019
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1060..1098
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1099..1139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1392..1431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1432..1473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1474..1514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1558..1595
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1668..1722
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1790..1830
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1848..1901
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2033..2077
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 22..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..844
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 187..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 205..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 424..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 442..451
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2089 AA; 226865 MW; 159A35F8E6680C55 CRC64;
MVKMDRTGLA VLLLLTVALG HSHKEASGGR KEFSGPERTP RDQHHHHHQQ QQQPPQGHIP
EGFTSSVSSG DTSPGSGSRQ SRTLVRLPRS ASSTTDGRST SRAGGAAAAA SVAGVSQPPA
PRDGAQRSGR QTSSSQQHRS RGNHRQSSSP GSGRTRRLVG PNVCGGHQCC SGWALAPGTN
RCIKPDCQPP CQNRGSCSRP HTCVCRSGFQ GARCEEVTPE QVYIRDGGTL RRVQPGTNPF
QKNQPRRRPS DRQAVGTTKV QSPRPAATRQ PAHTVTQVRR GPPDTSPQQT GTSRTVKRYP
SSSGPITSNA LPSGNSYNSR GSEQRNWNGH RSGQNTMHSF NGHRPSSDNQ LNSALYPAGA
NLTSNLDRIK IVFTPMKCRR VCSGGRCYNS CEKGDITTVY SETSQQQQQQ QQQQQNQGFR
LFFCQIPCLN GGRCIGRDVC WCPSNSTGKF CHLPVPVPAR TSPHSHKDPS HTGPSSHSMY
TLPLSNQQVS LHPSLVNVHI QHPPEAEIEI HQVARVQPGH RLAIPEGAHS VQQRSQPGNG
HEATIELNGR QLHFTGNENG NSHTRLQPRQ NGHVGRCFQE TVDGQCGKPL PGLTKQDDCC
GSVGASWGLH KCQKCPTKPA FTVIANGQVE CSKGFKRMNL THCQDINECL LPGICKNALC
FNTKGSYRCT CKPGFMLDAA RSHCVSDKAV SNQKGMCYRS VSADTCYLPL VQHITRQICC
CSRVGKAWGE SCDRCPLPES DHFKEICPAG HGYTYSLSDV QISLRQLEHD ELQSTGVTWE
DYLSTHLQPP SSQPSLQVPG RPQSPVYPEV PQVPQYPEYP ETPYVPHQPQ TPHRPQPPFQ
PDWDTPKEPD VETLSRPSVV TDSPVDYPGT SPPDSSVSNL SPDTKDTTQT HSSTGHDTCA
SAPTICGRGK CVPVQTGYTC HCEPGFKLSA LQTNCIDVNE CDEDPCEGKG RCLNSYGSYT
CQCHSGYSQV ITQNRKFCQD VNECSLPGKC QNGKCVNTEG SYTCECNTGF ARSWRGVCED
VDECRDPGSC PTGACVNTLG SFQCQACGPG FRAVGDRCVD VNECLNHTVC GSGRCVNTEG
SYRCNCFHGY ELSGNICHDV DECALPGVCL HGRCVNLDGT HQCICDTGYR VTPDSRTCED
VDECAAGNAC HSGICINNPG SYTCQDCRQG FKPSADGLQC EDVNECVQGD LCQGGVCVNT
HGSYTCTRCK AGYRLSQDWQ RCEDIDECQF LSTCANGICL NTEGSYTCEN CPTGYGVSHD
GEFCEDIDEC ALPITCPQGT CTNTLGSFTC INCRPGFTVS EDGQQCEDVD ECTMASLCPG
QLCLNSPGSY TCRSCDPGMQ LSEDGDGCED IDECQIPGVC PTGVCTNMAG SFSCMACDPG
FAVAPSGSSC EDVNECEDTS LCLGGQCSNT IGSFTCSCPA GLELVDGTFC KDINECLTVV
GICGEGECLN TEGSYLCICP DGYTTVNERT GCQDVDECSK DNVCLGGRCL NTDGSFLCLC
EAGFKFSDET SDCEDKDECK EFGSSVCGTW QCKNTIGSYR CFKGCQPGLE GEDTKDCDID
ECLNETICGN HGFCENTDGS YHCQCDRGYT NPAGDTTRCV DVNECEMSLA LCGGALCENF
DGSFLCICPS DNEEFDPVTS QCRSLDTDMT PPAAPEEPSS VPSAEERKQC YYNLNSANIC
DNVLSHNTTK QECCCTVGAG WGDNCEIHAC PVVGRDEYNQ LCPHGSGLLL VSLSSSQHLV
DQQPYIDANE CEMFGSEICK NGQCSNLFST YTCYCRSGFY YDNIRLECVD YDECKFANAC
ENGACVNTPG SFNCFCSPPL VLDGTRRRCI GLNNSEETVE PDHDVHVDIC WRRLDQDNVC
AQPLLGVRTT YTECCCLYGY AWSGQCAFCP GRDTVDYAVM CNLPTSRGGS DSLRERPGYE
YGVDEPEEPF LPPYWDNYGS PAGTYDTPES VPLFNDNDYS VQQPPVRVPI TPRERQPRPV
ETERYAGFEG LQAEECGILN GCENGRCVRV REGYTCDCFD GYELDLNKMA CIDINECEDI
NDKVPLCQNG TCSNTEGSYK CTCLPGFVAS AQPHKCIPTI PESGPRETN
//
