ID A0A3P8UIN7_CYNSE Unreviewed; 1363 AA.
AC A0A3P8UIN7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Zinc finger protein 536 {ECO:0000313|Ensembl:ENSCSEP00000000481.1};
GN Name=ZNF536 {ECO:0000313|Ensembl:ENSCSEP00000000481.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000000481.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000000481.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000000481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR Ensembl; ENSCSET00000000507.1; ENSCSEP00000000481.1; ENSCSEG00000000339.1.
DR GeneTree; ENSGT00940000156397; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF2; ZINC FINGER PROTEIN 536; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF16606; zf-C2H2_assoc; 1.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 136..163
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 164..186
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 288..316
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 314..342
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 360..387
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 388..415
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 665..692
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 761..788
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 219..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 148876 MW; A5754AAC9CAED576 CRC64;
MDESSLCLGV PSAVPDADAH LSNAILNGRY PISQKLHQLT NQLEHTFPDL HRSQQITEEK
VATPLEDKIN NAALAGQPIS SQMALLANQL NRDIDAGALS GLNGRVDLQQ FLNGQNLGIM
SHMNDIEDDT RKNRKYPCPL CGKRFRFNSI LSLHMRTHTG EKPFKCPYCD HRAAQKGNLK
IHLRTHKLGN LGKGRGRVRE ENRLLHELEE RAILRDKQMR GSGGLIQTPQ TPHLGLNNSN
NTSQPQLGSC GIAPPSGITT PDTVSQPSSS PKSTTTQDEH FLSPATGFRC TFCKGKFKKR
EELDRHIRIL HKPYKCTLCE FAASHEEELI NHVEKAHITA EPAQGQGAGG AGGVQTATEF
RCDICGQVFS QAWFLKGHMR KHKDSFEHCC QICGRRFKEP WFLKNHMKVH LNKLAIKSKP
PQPSEQELSA VNSMSSLAQE AHANLYSRYI SCLQGGFLSP DKQGLNEQHQ MLAKAGIAMK
EREMLGKLLG PMARSMGHAL GENEKQSLLG CLHLVPPLKS SCMERLQAAA KVAEMDSLSS
YQAWQIMARG TALDRAFMPK EQQHITQGQE EELGSVGALS SITKDKQDYS SIPSNDSSKQ
KQLSEALQGS KTSSGSMMTI KEDGRGFDGH HDLSYHSSAE TPGALAGLGS PNIDYSLSGL
KEKPSECPDC GRIFRTYHQM VVHSRIHSKD RRSMDEVLQQ QGLDERRGSA SDPESQSISR
STTPGSSNVT EESGAGGHSH TGSVQDDSPH PSSPSSGEKP YRCPHCDYAG TQSASLKYHL
ERHHRERQNS SASSGPSSTG HSTASDHKED HGKMAGGAIF ARPDILRSVF KGIPPNMDFR
AGPLLPHQWT SAGMMTPHDN NRERGDHRFD STSSVENLKM TDVASTLVST ATDGPANFSE
LGRAYQTMMG NGVPFQGSLQ AFMDNFVLGS MKKDLKDNQS PGQLKNQLYH DNGEPKAKRA
APTEHDKEDK PEIKKNSDPR KPGSQYEPLD LSVSVRPESA SGALPGSSVT VLDNVVWHGC
LFCSFSTSSF ELMALHLQAN HLSKTQLQRP NTSDTSSSNT KTSNVNKDGD KDGEKNQGGW
SNHVDQTYNP FQSEFYRRFG GLYDGSPGAN PSLQGFVTPA EQGLDIPNVS FEGTSSAGDE
QMAERSSHGE AEDDQGGSDD EVAKGDAAEA SLNSPRRLPR QIQYDEDEQD GVTEEDEEKD
QDIDGDNLQN HRKHHQEDFS FPPRSGAGLA ASSSSTMSSL SLGPPVQNHT MSLEKQWQQK
SLGLLASGGG HGLRNAEPYG HQDQQMNMLS VLRAYSNENM PTFNGLGGGA AGGTVKRPEV
PVHLWVGGED EDRPMTADPT LTLHPDSDLN NHSNGLNGGE VEG
//
