ID A0A3P8UIT4_CYNSE Unreviewed; 1705 AA.
AC A0A3P8UIT4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tight junction protein ZO-1-like {ECO:0000313|Ensembl:ENSCSEP00000003133.1};
GN Name=TJP1 {ECO:0000313|Ensembl:ENSCSEP00000003133.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003133.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003133.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003133.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR Ensembl; ENSCSET00000003178.1; ENSCSEP00000003133.1; ENSCSEG00000002031.1.
DR GeneTree; ENSGT00940000155164; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12026; SH3_ZO-1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005418; ZO-1.
DR InterPro; IPR035597; ZO-1_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF31; TIGHT JUNCTION PROTEIN ZO-1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01598; ZONOCCLUDNS1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 111..198
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 288..366
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 518..599
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 613..681
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 796..897
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 1584..1705
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 28..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..970
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1287..1302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1424
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1705 AA; 188486 MW; CDDAD07B773546F7 CRC64;
MKYQKYITVM QMAMGVTASN KDCLPSKRQL WVPPDGDASP TTPGYSDGPS GATGGAGAIA
SSSTLSLPMN QGKPSLRRIK GRIHRSKSLD SLDLLDNSAA MEETVIWEQH TVTLHRAPGF
GFGIAISGGR DNPHFQSGET SIVISDVLKG GPAEGLLQEN DRVVMVNAVS MDNVEHAYAV
QQLRKSGKNA KITIRRKRKV QIPVSRQGDR ETMSEHEEDS EEADAYDPQS GRENAYGAPA
GGTGTGRRHD HERSSSGRRD HSASRERSVS PRSDRRSQTS SAPLRPSKVT LVKSRKTEEY
GLRLASHIFV KDISPESLAA RDGNIHEGDV VLKINGTVTE NLSLIDAKKL IERSKGKLKM
VVQRDERATL LNVPDMDDSI PSANNSDRDD ISEIHSLTSD HSNRSPGRGR SRSPDRPDTA
DHLRHSPRQI SNGSHRSRDE ERSSKPGAMS TPVKSSDDGV LSQASDQASS RDDKSLPPLP
EPKPVYAQPG QPDVDLPVSP SDAPVPSAAH DDSILRPSMK LVKFKKGESV GLRLAGGNDV
GIFVAGVLED SPAAKEGLEE GDQILRVNNV DFANIIREEA VLFLLDLPKG DEVTILAQKK
KDVYRRIVES DVGDSFYIRT HFEYEKESPY GLSFNKGEVF RVVDTLYNGK LGSWLAIRIG
KNHHEVERGI IPNKNRAEQL SSVQYTLPKT PGGDRADFWR FRGLRSSKRN LRKSREDLSA
QPVQTKFPAY ERVVLREAGF LRPVVIFGPI ADVAREKLAR QEPDIFELAK TQKQQGGEKS
EPRDAGTDQK NSGIIRLHTI KQIIDRDKHA VLDITPNAVD RLNYAQWYPI VVFLNPDHKQ
GVKSMRTRLC PESRKSARKL YDRALKLRKS NHHLFTTTIN LNSMNDGWFG ALKETIQQQQ
NQLVWVSEGK ADGAGEDDLD IHDDRLSYLS APGSEYSMYS TDSRHTSDYE DTDTEGGAYT
DQELDETLND DVGPPIEPAI TRSSEPVRDD SPVIQDPPGY SGYPHTVQPH PLNRIDPAGF
KVPVPQQMLQ KDPFSKDTMG RNSQGMKPVT YNTQQGYHPD QQPYRNYDHP PSRYDVSSSG
VSSAGGYVEP KYRNYDSNLP FENSVPHYDQ QQWNPYSQSL STANSQSFDH QLPYDDGPDP
EYTPPLRYDE PPPQQGYDGR PRFGKPTGPG PVRYDDPPPP APGRDKHYDQ DSFLTTYPAA
ARSPEPTSQR PSYNQGPPPQ QKGYKPQQYD PIPVNSDTSA TPPPKAENSS PSLLDAPKSA
PVRDEKPEDD PAMKPQSVLT RVKMFENKRS VSMDRARDAG ESSANKAADL PLKSGGVIPK
ANSLSNLDQD KAYRATEPQK PQTKGADDIV RSNHYDPDED EDYYRKQLSY FDRLQTGPNK
PQAQITHNFS RTESGEIPSL LEKKHEPVPQ VTPPLPPATL PKPSTEVKPP AREDTVQTNF
LPHKSYPEKS PVNGTSEQPT KPLTSTGAPP ASTYNRFMTK PFTTSAKPFS RMFDSPKFNH
NLLPNDKPDT APKGVSSSPV KQPQIPPQTQ NLDHDSGVDT FTRTMDHRSK YQNNNITAVP
KAIPVSPSAL DDDEDEDEGH TVVATARGIF NSNGGVLSSI ETGVSIIIPQ GAIPEGVEQE
IYFKVCRDNS LLPPLDKEKG ETLLSPLVMC GPHGLKFLKP VELRLPHCAS MTPDGDPKSW
QNKSLPGDPN YLVGANCVSV LIDHF
//
