ID A0A3P8UIX4_CYNSE Unreviewed; 617 AA.
AC A0A3P8UIX4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase activating protein 4 {ECO:0000313|Ensembl:ENSCSEP00000001799.1};
GN Name=ARHGAP4 {ECO:0000313|Ensembl:ENSCSEP00000001799.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001799.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000001799.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000001799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8UIX4; -.
DR Ensembl; ENSCSET00000001831.1; ENSCSEP00000001799.1; ENSCSEG00000001164.1.
DR GeneTree; ENSGT00950000182824; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 19..317
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 477..617
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 195..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 7..45
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 617 AA; 70088 MW; AD82AFDD84ADE544 CRC64;
MTSHVKLRKE KGSLAEYESQ MKDLRTQLTD QIKILDSQVE VKQQQLSDLS EFLRRRGDIE
AEYARALDKL TERFTSNGSM CVCVCVCLFS RKEQWYKSVC QVWSVLLTQT RLESREHAAL
GDTCCNTLTQ RLTHSMEDTH RLHKRVSGRH KEVGVQMQDE LIKVTTELQT ALKTYNQYHT
DCLIAEGKLK EAERLEERHT GKSSELGLGQ SSGQRRSSVK KMERLMEKVK IMRETQLKCT
KARNDYLLNL AAANAEMNKY YLQDVSTLID CCDLGFHLSV DRVIRCYLAS RWRIQKAEET
GLKQLETAMT SLDQSGDRDA LLQQHDAAFC LPFRFNYHPH EGDQVCEVSA ESQVRYELET
RFQQLQSRLA AVTLETEEIS KTLKATLASL LDTMCNGDSN SAPDVTSSQS HDTIGGVSAP
KLAIAKRRAN QQETETYYFT KVKEFLTSSS LSSKLQAKHD LLQDAIQKGS LFIFSTSPLH
HCSPHIVIPH STMFSSLFLS SSLPVFPLLQ SSGQQIPVVV ESCIRFINLH GEDPLSDSEC
DLDSVAGVLK LYFRGLEPPL FPYDSYTQLL DCVRKTNNPA ETKQSPCCFY LCLCLHITSW
KQWPCLTTRP DLQQNSP
//
