ID A0A3P8UK39_CYNSE Unreviewed; 1408 AA.
AC A0A3P8UK39;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 {ECO:0000313|Ensembl:ENSCSEP00000001001.1};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSCSEP00000001001.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001001.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000001001.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000001001.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSCSET00000001029.1; ENSCSEP00000001001.1; ENSCSEG00000000676.1.
DR GeneTree; ENSGT00940000157675; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 621..716
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 730..838
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 874..1029
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1040..1366
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 164..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 157339 MW; 844C63A4283CF64F CRC64;
MADGEDTMSQ EDWKEKCMVL EALLMKFRMQ IIKIRELTAD KIQQLETQVI DAEKRAFTAH
QQVQWMEEKL NPPEGQSAEA EVNLFQRCQE LQARLQEKDD LIGRLEQQLE EQKQSRLVDA
KTVEEKAAKI KEWVMLKLSE FEVENAALRE NNKKQEAQIL ELQNQVQGEK DSGGRGAPSR
PGGAQRLSSL TFGCFQVRGK NPQVLTGPTP SQRTLSTQEE SDVSGESSQR HGCRELNKRF
HASESLAEIV SGEESRGVSS VLSSAASEGE AEGGGGVCGL GFSRPGSDTY LTASDDSSSV
FDDDMQRAER PGFGLLGPSD GSLEGSKEGE DEESRRVRLE ESTSEELNKR FQSQRLDSNE
PNSPSAPLTS ALTPKRPTPP QDPRDNPASP KQPRLRTPAG LGLINASLSK KHLSQPPLSA
ETTDGKTRNA LSMLHPLSPL DTDPDQRGEA GMETTRRTPP KVLPRSQAPA LPGPKGDRDS
DVTGPDRTPP TPPLHRLPSW ESRIYAVAQS GIRLSETTSF LMFTSLVYKN LTSPVYTTLK
GVSGAVLVSM KGFSCRVRRL VPPPPSTSPP LSAAVSMSSM TSESDYAIPP DAYSTDTENF
EPEHKLPKTC SGASDNGKTE PMEKSGYLLK MVRTWKKTWK RRWFVLKDGE LLYYKSPSDV
IRKPQGQIEV NASSNIARGD GKQILQIVTG KRVYYLKADS PNLLDEWLRV LLSVLRVKAA
SPLFTQPDIR PGMKGLLIKV KHGYSKRVWC ALIGKTLYYF RSHEDKFPLG QIKLWEARVE
EVDRSRDSDD DLKACGRGLQ GAHFTIAVHP QEQGPTYLLI ESRHEKDAWL YHLSVAAGTT
VGDVGTEFEQ LVGKLFQLDG DPNSQIWRHP TLCFSKEALW SPLTTLPSQA LQTEAVKLFK
TCQLFINVAI DAPAIDYHVS LAQSALQVCL AHPELQNELF CQLIKQTSRR QPPGQPGPLQ
GWQFLALCVG LFLPQHPFLW LLQVHLKRHG DSRTEVGKYA IYCQRSMERT QQKGERQSRP
SRMEILSILL RNPYHHSLPF SVPVHFLNNT YQVVSFDAST TVDEFQSRLN QDTGMRKNGL
SGFSLYTDDP TGRELEHCLQ GSIKICDIIS KWEQASKETH TGKSENTRTV RLTYKNRLYS
SLQVRGEVER ERSLLAYQTN EAIVSGHFPV NKELALEMAA LLAQLEFGDF ERPFSAAGSA
QTKSNQTLKQ VLERFYPKHY RRTSTEEQLR QLLQRLSARW ASLRGRSSSE CVRIYLTVAR
KWPFFGAKLF EAEVKPGVRV WLAVHEDGVS VLEHNSIKPL VSHSYKNLMT FGGCRQDFML
VLGHSVGANS TRDKPTEKHL FSMDSSKVRE ITLLISSYIN NAHQQKAAAH HLSAPALLVA
QPISLKSKEL RSKSPPVLGR PSKTPTLL
//