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Database: UniProt
Entry: A0A3P8UK39_CYNSE
LinkDB: A0A3P8UK39_CYNSE
Original site: A0A3P8UK39_CYNSE 
ID   A0A3P8UK39_CYNSE        Unreviewed;      1408 AA.
AC   A0A3P8UK39;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 {ECO:0000313|Ensembl:ENSCSEP00000001001.1};
GN   Name=PLEKHH2 {ECO:0000313|Ensembl:ENSCSEP00000001001.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001001.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000001001.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000001001.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSCSET00000001029.1; ENSCSEP00000001001.1; ENSCSEG00000000676.1.
DR   GeneTree; ENSGT00940000157675; -.
DR   Proteomes; UP000265120; Chromosome 12.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR   PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          621..716
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          730..838
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          874..1029
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          1040..1366
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          164..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..387
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1408 AA;  157339 MW;  844C63A4283CF64F CRC64;
     MADGEDTMSQ EDWKEKCMVL EALLMKFRMQ IIKIRELTAD KIQQLETQVI DAEKRAFTAH
     QQVQWMEEKL NPPEGQSAEA EVNLFQRCQE LQARLQEKDD LIGRLEQQLE EQKQSRLVDA
     KTVEEKAAKI KEWVMLKLSE FEVENAALRE NNKKQEAQIL ELQNQVQGEK DSGGRGAPSR
     PGGAQRLSSL TFGCFQVRGK NPQVLTGPTP SQRTLSTQEE SDVSGESSQR HGCRELNKRF
     HASESLAEIV SGEESRGVSS VLSSAASEGE AEGGGGVCGL GFSRPGSDTY LTASDDSSSV
     FDDDMQRAER PGFGLLGPSD GSLEGSKEGE DEESRRVRLE ESTSEELNKR FQSQRLDSNE
     PNSPSAPLTS ALTPKRPTPP QDPRDNPASP KQPRLRTPAG LGLINASLSK KHLSQPPLSA
     ETTDGKTRNA LSMLHPLSPL DTDPDQRGEA GMETTRRTPP KVLPRSQAPA LPGPKGDRDS
     DVTGPDRTPP TPPLHRLPSW ESRIYAVAQS GIRLSETTSF LMFTSLVYKN LTSPVYTTLK
     GVSGAVLVSM KGFSCRVRRL VPPPPSTSPP LSAAVSMSSM TSESDYAIPP DAYSTDTENF
     EPEHKLPKTC SGASDNGKTE PMEKSGYLLK MVRTWKKTWK RRWFVLKDGE LLYYKSPSDV
     IRKPQGQIEV NASSNIARGD GKQILQIVTG KRVYYLKADS PNLLDEWLRV LLSVLRVKAA
     SPLFTQPDIR PGMKGLLIKV KHGYSKRVWC ALIGKTLYYF RSHEDKFPLG QIKLWEARVE
     EVDRSRDSDD DLKACGRGLQ GAHFTIAVHP QEQGPTYLLI ESRHEKDAWL YHLSVAAGTT
     VGDVGTEFEQ LVGKLFQLDG DPNSQIWRHP TLCFSKEALW SPLTTLPSQA LQTEAVKLFK
     TCQLFINVAI DAPAIDYHVS LAQSALQVCL AHPELQNELF CQLIKQTSRR QPPGQPGPLQ
     GWQFLALCVG LFLPQHPFLW LLQVHLKRHG DSRTEVGKYA IYCQRSMERT QQKGERQSRP
     SRMEILSILL RNPYHHSLPF SVPVHFLNNT YQVVSFDAST TVDEFQSRLN QDTGMRKNGL
     SGFSLYTDDP TGRELEHCLQ GSIKICDIIS KWEQASKETH TGKSENTRTV RLTYKNRLYS
     SLQVRGEVER ERSLLAYQTN EAIVSGHFPV NKELALEMAA LLAQLEFGDF ERPFSAAGSA
     QTKSNQTLKQ VLERFYPKHY RRTSTEEQLR QLLQRLSARW ASLRGRSSSE CVRIYLTVAR
     KWPFFGAKLF EAEVKPGVRV WLAVHEDGVS VLEHNSIKPL VSHSYKNLMT FGGCRQDFML
     VLGHSVGANS TRDKPTEKHL FSMDSSKVRE ITLLISSYIN NAHQQKAAAH HLSAPALLVA
     QPISLKSKEL RSKSPPVLGR PSKTPTLL
//
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