ID   A0A3P8UK67_CYNSE        Unreviewed;       822 AA.
AC   A0A3P8UK67;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Dipeptidyl peptidase like 6 {ECO:0000313|Ensembl:ENSCSEP00000001031.1};
GN   Name=DPP6 {ECO:0000313|Ensembl:ENSCSEP00000001031.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001031.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000001031.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000001031.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8UK67; -.
DR   Ensembl; ENSCSET00000001059.1; ENSCSEP00000001031.1; ENSCSEG00000000664.1.
DR   GeneTree; ENSGT00940000156280; -.
DR   Proteomes; UP000265120; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF206; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 ISOFORM X1; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        74..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          172..531
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          602..803
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          32..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  93199 MW;  276C421A29C3A21A CRC64;
     MASLYQRFSG KINTGTSFPN PPEASHLLGQ SAEVEQQRPA LQPRLQPQQQ LRRRPEDEDE
     LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPGDD DRLALKSKVS VGDLSRKDFK
     VHDPNAKWIS TRLVKGLIFV SPPTPSLSYL PLPSLVLSQP QEMYKASKYQ VSPDMKHVLL
     AYNVAPVSGV FFLSFFYEET WNLNPPEVRN AQLQYAGWGP RGQQLIFIFE NNIYYRSTVE
     SRSIRLVSTG KEGVIFNGLS DWLYEEEIFR SHVAHWWSPD GARLAYATIN DSLVPRMELP
     MFTGTLYPMG KEYHYPKAGE ENPVITLYVV NLNGPLHTIQ MRKPEDPRIR WDYYVTMVKW
     ATSTKLAINW LNRAQNISIL TLCEATTGVC TKKHEDESEG WLHRQNEKPL FSKDGLRLFF
     TRAIPQGGRG KFYHISMSVS QPNTSSDTLQ SITSGDWDVT QVLAYNEESQ LIYFLSTEDG
     PKRRHLYSAD TFGSFNRRCL SCAMSDSCGY ISGSFSHNMS YFLLSCQGLS TVQRCTIQVF
     KLENNEVLRV TLDSMQMPTV ECRKSLSLQI LKPATFMETS HYPLLLLVDG TPGGQTVSEQ
     FHMDWFTVLI SSFEVIVVRC DGRGSGFQGT NLLHRIQKKV GVFEEQDQKS ALSFLLKESY
     VDKSRVGAFG KVYGGYVTSL LLSGEETPVK CGAVLSPVTD FELYASAFSE RFLGLPKPDP
     RAYAMANLAH RASQFVEKKF LIIHPTADEK VHFQHSAKFI SQLINEKANY TLQIYPDEGH
     FIQSEATRQH LTQSLVNFFE ECFRLPERVF EEVLEEESED EG
//