ID A0A3P8UM57_CYNSE Unreviewed; 469 AA.
AC A0A3P8UM57;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=RAP1 GTPase activating protein 2a {ECO:0000313|Ensembl:ENSCSEP00000004283.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000004283.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000004283.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000004283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8UM57; -.
DR Ensembl; ENSCSET00000004338.1; ENSCSEP00000004283.1; ENSCSEG00000002764.1.
DR GeneTree; ENSGT00940000165230; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 175..381
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 41..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 52987 MW; DE2DE5880BA08A21 CRC64;
SPSVYQDDYI PYPRIEDVLE KGGPYPQVIL PQFGGYWIED AEAPAGTPSS SESSFCEEED
REDGMSPGGG HSYRLECNST ARAYRKHFIG KEHMNYYCTG SSIGNLIMSL KHEEAEGQEF
LRIMLRSRTK TVHDRVSLAG LNQLPTVPQI AKLLCDDATG LRFNPVLYPR GSQLIVAYDE
HEVNNTFKFG VVYQKFGQTS EEELFGNNEE TPAFKEFLGI LGDNIELQDF KGFRGGLDVS
HGQTGSESVY TVFRQREIIV NFRHFSSEIS SLQRKRHIGN DIVAAVFQEE ATPFVPDIIA
SNFLHAYVLV QVENPCTDHT TYKVSVTARE DVPPFGPLLP NPAVFKKYRH VKLINAENAC
YKSDKFAKLE GRTRAALLDN LHDELHRQSQ ATLGLGQPGE EDKLENGGHG GLLESFKVII
CQNFANIMTY SFGDDYFCRQ IIFHRNKVAT FIMTNAQVYI NNREIKLYF
//
