ID A0A3P8UMY0_CYNSE Unreviewed; 2364 AA.
AC A0A3P8UMY0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000002011.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000002011.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000002011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 244447.ENSCSEP00000002011; -.
DR Ensembl; ENSCSET00000002047.1; ENSCSEP00000002011.1; ENSCSEG00000001351.1.
DR GeneTree; ENSGT00940000157157; -.
DR InParanoid; A0A3P8UMY0; -.
DR OMA; TCHEQRD; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 26.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 33.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 18.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 30.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 29.
DR PROSITE; PS01186; EGF_2; 23.
DR PROSITE; PS50026; EGF_3; 33.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..35
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 38..75
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 76..112
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 114..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 193..229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 271..307
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 308..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 348..386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 388..424
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 442..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..515
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 517..553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 555..590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 592..628
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..665
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 667..703
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 705..741
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 768..804
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 806..842
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 844..880
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 882..918
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 920..956
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 958..994
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1007..1042
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1044..1080
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1082..1118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1120..1164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1166..1204
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1206..1245
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1247..1283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1286..1324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1348..1388
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1389..1426
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1427..1470
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1813..1845
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1880..1912
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1913..1945
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1946..1978
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1666..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2221..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2292..2364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2048..2071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2292..2315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2323..2364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 368
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 371
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 388
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 389
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 391
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 405
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 406
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 25..34
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 65..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 102..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 142..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 219..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 259..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 297..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 317..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 336..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 352..365
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 359..374
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 376..385
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 392..403
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 397..412
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 468..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 484..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 505..514
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 543..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 559..569
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 580..589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 618..627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 634..644
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 655..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 693..702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 794..803
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 832..841
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 870..879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 908..917
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 946..955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 984..993
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1070..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1108..1117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1154..1163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1175..1192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1194..1203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1235..1244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1273..1282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1295..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1314..1323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2364 AA; 256226 MW; FE8446936BE5D321 CRC64;
PSPCRNGGEC RPISHGNTFD FHCVCRLGFT DRLCLTPANH ACMSSPCRNG GTCDLISLSV
YHCRCPPGWT GKSCQLANPC ASNPCANGGQ CSAFDSTYIC TCPPAFHGQT CKQDVNECAQ
TPSPCLNGGT CVNEVGSYHC RCPQEYAGKH CDSRYMPCSP SPCQNGGTCV QKGDTTYGCS
CLPGFTGQNC EHNIDDCPGH SCQNGGVCVD GVNTYNCRCP PHYTGQYCTE NVDECELMPN
ACQNGGTCHD THGSYHCVCV NGWTGDDCSE NIDDCASAAC YHGATCHDRV ASFFCECPHG
RTGLLCHLDD ACISNPCQKG SNCDTNPVNG KAICTCPPGY TGSACNLDID ECSLGANPCE
HGGRCLNTKG SFQCKCLQGY EGPRCEMDVN ECMSNPCHND ATCLDQIGGF HCICMPGSEN
IILILYLSIE LAGFSGNLCQ VDIDECASTP CKNGAKCTDG PNKYTCECAE GYTGQHCDID
VNECYSDPCH YGTCKDGLAS FTCYCHPGFT GRLCETNINE CLSQPCKNGG TCQDRENTYM
CLCPKGTAGF NCEVNLDDCK NKPCDYGRCI DKINGYECAC EPGYTGVMCN INIDECAINP
CHNGGTCVDG INSFTCLCPE GYNDATCLSQ VDECSSNPCI HGRCQDLING YKCTCDSGWS
GKNCDINNNE CESNPCMNGG TCKDMTSGYH CTCRTGFTGP NCQTNINECA SNPCLNQGTC
IDDVAGYKCV CMLPYTGMTF LHYLVFTTHS PVCVGGAHRS RSQTCEFDIN ECVKSPCRNG
GICHNTMGGY QCKCQPGYTG QKCETDVDDC KPNPCSNGGL CHDGINSFTC TCLPGFRGGR
CEQDINECES NPCRNGANCT DCVNSYTCTC PPGFSGINCE INTNDCTDSS CFNGGTCVDG
INAFTCLCLH GFTGSYCQYD INECDSKPCL NGGTCYDGYG TYKCTCPHGY TGINCQNLVR
WCDSSPCKNG GSCWQQGASY TCQCQTGWTG LYCDIPSVSC EVAAKQQGVD VANLCRNSGQ
CLDAGNTHYC RCQAGYTGSY CQEQVDECLP NPCQNGATCT DYLGGYSCEC VPGYHGVNCS
KEINECQSQP CQNGGTCIDL INTYKCSCPR GTQGVHCEIN LDDCNPSIDP LTKEPKCFNN
GKCVDRIGGY QCVCPAGYVG ERCEGDVNEC LSDPCDPRGS YNCIQLTNSY HCECRTGYTG
QRCDKVFDGC KGKPCRNGGT CAVASNTPHG FICKCPPGFT GSSCEYDSRS CGNLNCRNGG
TCMSGHLGPR CLCPPTFTGP ECQMPTDNLC ISNPCYNGGT CQITSEAPFF HCSCPSNFNG
LLCHILDYSF VGGFGRDITP PPEVEVSCEI PQCDEWAGNH ICDSLCNNHA CGWDGGDCSL
NFDDPWQNCS AALQCWRYFN DGKCDGQCNS PGCLYDGFDC QGQEGQCNPL YDQYCKDHYA
DGHCDQGCNN AECEWDGLDC ANNMPEKLAD GHLILVVHIP PEQLKNHSSA FLRDLSSVLH
TNVVFRRDVR GEPMIFPYYG NEQDLVKHNM LKRSADGWPE WATMPASVLG QVKERVSSMV
SPRKRRELDP VQVKGSVVYL EIDNRQCYQQ STESLASSGN LNVPYIEAVT SVRPTQSNSE
LYPMYVVFLG LAALGFVCLG VLVSRKRRRE HGQLWFPEGF KVSEPTKKKR REPLGEDSVG
LKPMKNSDIN LMDDHQNDWD DEDPDCRRFR FEEQAMLDLS DHTDQRKWTQ QHLDAADLRI
QSIAPTPPQG EIENDCMDVN VRGPDGFTPL MIASCSGGGM ETGNSEEEED PSAEIISDFI
YQGANLHNQT DRTGETALHL AARYARSDAA KRLLESSADA NVQDNMGRTP LHAAVAADAQ
GVFQILIRNR ATDLDARMHD GTTPLILAAR LAVEGMVEEL INCHADANAT DESGKSALHW
AAAVNNVEAA VVLLKNGANK DMQDNKEETP LFLAAREGSY ETVKVLLEHF ANREITDHLD
QLPRDIAQER MHHDIVRLLD EYNVVRSPGL HSAPISTANF SPPLCSPNDY LSNLKPNLSG
KKVRKISSAG KGGKDGGKDN RLKKKKSMDG KNNLLDTSAV LSPVDSLESP HGYLSDVASP
PMTSPFQQSS PMSLNQLQGN ADSHMGQMTM GKDMGCMSFD PNPPRLSHLP VSSPSGQGAA
SLGANRGGQC DWVSRMHPGQ QGGFTQAPSM THNMMGPLHG VSTATLSQIM GYQNLQTSHL
SSPAHMMQQG RSRQLQHQNS NSTTTGQPRN PGFPNIELNG SDMQQNIGSG RSMPIHTVMP
QETQILSAQF LTPPSQHSYN GPMDNTPNHQ LQVPDHPFLT PSPGSPDQWS SSSPHSNMSD
WSEGISSPPT SIHSQMNLIP EQFK
//
