ID A0A3P8UN54_CYNSE Unreviewed; 205 AA.
AC A0A3P8UN54;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000001685.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000001685.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000001685.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000256|ARBA:ARBA00008344}.
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DR RefSeq; XP_008309751.1; XM_008311529.2.
DR AlphaFoldDB; A0A3P8UN54; -.
DR STRING; 244447.ENSCSEP00000001685; -.
DR Ensembl; ENSCSET00000001716.1; ENSCSEP00000001685.1; ENSCSEG00000001146.1.
DR GeneID; 103379835; -.
DR KEGG; csem:103379835; -.
DR CTD; 566719; -.
DR GeneTree; ENSGT00940000167685; -.
DR InParanoid; A0A3P8UN54; -.
DR OMA; WADACLL; -.
DR OrthoDB; 5481717at2759; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd04146; RERG_RasL11_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45704; RAS-LIKE FAMILY MEMBER 11; 1.
DR PANTHER; PTHR45704:SF2; TRIPARTITE MOTIF-CONTAINING 66; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
SQ SEQUENCE 205 AA; 23492 MW; 4BBF33FF6F4765AC CRC64;
MNDIKLALLG SEGAGKSAVL VRFLTRRFIG EYASNTNSLY HKRLSIDGRQ LNLEVFDPCS
QSSETRCILE EPVDWADGFV VVYNISDRTS FINAENILRQ IREARVDSCK GEMEVPVCLV
GNKQDLCHVR QVYEEEGRCL AQENHCTFQE VSAAESYQDI ANLFTRLIRQ TMEHLKYRAD
RRRYSGSKSM AKLINNVFGK RRKSV
//
