ID A0A3P8UNE7_CYNSE Unreviewed; 1074 AA.
AC A0A3P8UNE7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003887.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003887.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003887.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A3P8UNE7; -.
DR STRING; 244447.ENSCSEP00000003887; -.
DR Ensembl; ENSCSET00000003936.1; ENSCSEP00000003887.1; ENSCSEG00000002492.1.
DR GeneTree; ENSGT00940000166134; -.
DR InParanoid; A0A3P8UNE7; -.
DR OMA; HTELHHI; -.
DR Proteomes; UP000265120; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 431..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 499..772
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 844..974
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1037..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 781..808
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1074 AA; 120242 MW; 66F75F8FBECC7D55 CRC64;
MRHTSPNFRG ALWDSHHACV PVVKSRPTTT TVPFHNVIFW VLLGVLTYPC CVRCLVFKVG
VLGPWNCDPV YSRAQPAAAA KLALSRISGD PNLDLGLRMD FVILQEPCET SKALNAFVSY
EQMSDAILGP TNPVYCVAAS LLAKNWDKAL FSFGCLSYEL DRAMGYPTFA RTVPFSVDVL
YAVLKQFSWA SVAVVSSNED MWVGTAGRVA TALRNRGLPV RLVTPTGVNE TAVENVLMKI
KAAGEVRGQS TPLPYTNVSY KALQNNSRLR EAYDAVLTIT LASEPLSFNE AFTAAKSNKE
LEITTLAEQV NPLFGTIYNS IYILAHSIHR TRRAGVKLSG SNLAFHTKNI TFTGFNQNMK
VDSAGEVKAN YVVLDTDRGG SQLFQTYVVN TVSGKLQWAG RSISFPGGSP PPSDSRCWFD
KNTICTGGVE VTYIIVVLAV IASLAVGGLT LSLYVRRRLQ QIQLFKGPNR ILLTIEDLTF
INPQLSKKKI TLEDLSESKS AVDDRSVGRS HSVNSILTTT HETTNVAVYE GDWVWLKKFE
EGQFKEVKQT TTKIFTKMKD LRNENVNPFL GFFSDCPMFA VVTEHCSRGS LQDLLRNEDV
KLDWMFKSSL LLDLIKGMKY LHHRDFAHGR LKSRNCVVDG RFVLKITDHG FNELLDSQKA
PIKQCPPEDL FWTAPELLRE VANSRKGTYK GDVYSFSIIL QEVVVRGPPY CMLGLPPEEI
IRKVKKPPPM CRPTVAPDQA PLECIQLMKQ CWSELPDRRP NFDEIFDRFK IINKGKKTNI
IDSMLRMLEQ YSSNLEDLIR ERTEELEVEK QRTEKLLSEM LPPTVADALK TGATVEPEHF
DQVTIYFSDI VGFTTISSLS EPIEVVDLLN DLYTLFDAVL RNHDVYKVET IGDAYMVASG
LPKRNGNKHA AEIANMSLNI LSSVGTFKMR HMPDVPVRIR IGIHSGSCVA GVVGLTMPRY
CLFGDTVNTA SRMESTGLPY RIHVNITTVN ILHSLNEGYK IEVRGKTELK GKGIEETYWL
HFINFFFFFY QGQLAGDDDR GDQDTFSQGQ KAGGQKELNE QKKKKICEIK AQED
//
