ID A0A3P8UNJ3_CYNSE Unreviewed; 434 AA.
AC A0A3P8UNJ3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Keratin, type I cytoskeletal 18-like {ECO:0000313|Ensembl:ENSCSEP00000003414.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000003414.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000003414.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000003414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008316448.1; XM_008318226.1.
DR AlphaFoldDB; A0A3P8UNJ3; -.
DR STRING; 244447.ENSCSEP00000003414; -.
DR Ensembl; ENSCSET00000003459.1; ENSCSEP00000003414.1; ENSCSEG00000002241.1.
DR GeneID; 103384641; -.
DR KEGG; csem:103384641; -.
DR GeneTree; ENSGT00940000163961; -.
DR InParanoid; A0A3P8UNJ3; -.
DR OMA; REWGHYF; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF377; KERATIN, TYPE I CYTOSKELETAL 18-RELATED; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 87..398
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..125
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 196..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 296..390
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 434 AA; 48449 MW; CD4287A006DAA64A CRC64;
MSIQQTYSMR TSSSGSSRPV GGGSFTRTSG PVYRANTIHG ISGGSRISVS SARAGLGAGM
PLASGVSGGF SSSVQVSGNS ADIMGNEKFA LQNLNDRLAN YLETVRNLEQ ANNKLELKIK
EALEKSGPDF RDYSKYQAIL DDLRRKVFDA TTDNARLVLN IDNARLAADD FRVKYESELA
IRQSVEADIV GLRKVIDDTN MSRMNLESEI EALKEELIHL KKNHGNDVME LRNQIAQSGV
HVDVDAPKGQ DLAQIMAEIR AKYEKMALQN QEELKTWHEA QMTEVQTQVT MNTEALKGAQ
TEVNELRRQI QTLEIELESQ KSLKASLEGT LRDTEMRYNM EMESLNNIIM SLEAELTQLR
NNIQQQTQDY EQLLNMKMKL EAEIATYRRL LDGGDFKLMD ALEDQKSVKT KVMTVTQTMV
DGKVVSSSTE TKTL
//
