ID A0A3P8UPR4_CYNSE Unreviewed; 1406 AA.
AC A0A3P8UPR4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Slit homolog 3 protein-like {ECO:0000313|Ensembl:ENSCSEP00000005173.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000005173.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000005173.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000005173.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCSET00000005232.1; ENSCSEP00000005173.1; ENSCSEG00000003303.1.
DR GeneTree; ENSGT00940000159322; -.
DR OMA; PACNANS; -.
DR Proteomes; UP000265120; Chromosome 15.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF9; SLIT HOMOLOG 3 PROTEIN; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 3.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 784..819
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 821..860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 862..898
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 900..938
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 940..976
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 985..1021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1024..1208
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1245..1280
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1284..1320
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1325..1405
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 809..818
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 850..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 888..897
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 928..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 966..975
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1011..1020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1249..1259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1270..1279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1288..1298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1310..1319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1406 AA; 154108 MW; D12470FB9AFA58D0 CRC64;
MRLDLSENQI QAVPRKAFRG ITNVKNLQLD SNHISCIEDG AFRALRDLEI LTLNNNNITL
IPLSSFNHMP KMRTLRLHSN NLHCDCHLSW LSDWLRARRG LAPFTQCMAP AQMRGLNVPD
VQKKDFVCNG PAQTELRTCV PQVAVCPASC TCNNNIVDCR RKGLTDIPAN LPESIVEIRL
EQNLIKSVPP GAFTAYKKLK RIDLSKNQIS DIAADAFSGL RSLTSLVLYG NKITELPKGL
FDGLVSLQLL LLNANKINCL RVNTFQDLQN LNLLSLYDNK LQTISKGLFA PLRSIKTLHL
AQNPFMCDCH LKWLADYLFD NPIETSGARC SHPRRLANKR ISQVKGKKFR CTGQEDYRSR
LSGECFQDLV CPEKCRCEGT VVDCSNLKLT RIPPHIPEHT TDLRLNDNEI AVLEAAGTFK
KLPNLRKINL SNNKLRDIRD GAFDGGSGVL ELLLTGNKLT GIQGRMFKGL TGLKTLMLRS
NQISCIDNQT FTGLNSVRLL SLYDNRISSI APGAFSTLHS LSTINLLSNP YVCDCHLSWL
GQWLKKTRVV SGNPRCQKPA FLKEIPIQDV ATPDFTCDGA EDNGCLPASG CPDVCTCSDG
VVRCSNRGLH SLPKGIPKDT SELYLEGNLL TSVPKELASL KQLLLVDLSN NSISTLAPYT
FSNMTQLATL ILSYNQIRCI PVHAFDGLKS LRLLTLHGND LSTIPEGAFN HLTALSHLAL
GANPLYCNCD LRWLSQWVKA GFKEPGIARC TGPPDMADRL LLTTPLNRFQ CKGPVDINLL
SKCVPCLANP CQNNGTCVPE SSGSYHCTCP YGFKGQNCEI PINACISFPC ANGGTCHIQS
GHEDHYSCVC LPGFEGQRCE VNPDDCEDND CENNSTCVDG VNNYTCICPP NYTGDLCEEV
VDPCLPGFDP CQHDSKCVHM GRSYRCDCLP GYVGQQCEQD YNDCLENKCQ HGAECVDAVN
GYTCVCKEGF SGLFCENPPP MILLQTSPCD QSDCQNGAQC IVTAGEPVCR CMPGFYGSKC
DKTATVHFLG RDAFVELPGV KLRPTAHISL QVATEKDNGL LLYKEDHDPL ALELYQGHIR
LIYDIANYPP TTVYSVESVN DGLFHTVELL IQNRSLSLVV DNGAPKSLSK LTRQPSVDHN
TQLYIGGVSS QVVATGLRPG PERPPQAFNG CIHNVRINGE LQDLSYRVAS GGRPQGVDSK
ADGILAGCHA CSVCAQGVCR EGGETGVTCE CPPGRSGSLC EQTTTPTACQ NNRCVNGVCV
LKGQSYSCQC NEGYQGQYCD RRQEPLACRG QRCTHGECKV SEAGEPVCVC QSGYTGANCD
TELTCHGEMV REQLKRHHPM RTCTSTSRIP RMDCPRSCQA AAPPGVCCGI TKSRKRKVVF
RCTDGTSYSE EMETALECGC SNKCPL
//
